NSLHD News - 31 October 2025

Next generation of researchers to build on remarkable legacy

Leading pain specialist Professor Chris Vaughan is stepping down after a career spanning close to three decades. As a principal hospital scientist, Chris has successfully juggled roles as a researcher, mentor and educator at Royal North Shore Hospital, the Kolling Institute and the University of Sydney. He has had a profound impact on the field of pain research, advancing our understanding of the mechanisms that control pain, and cannabinoid actions in the brain. In recent years, Chris and his lab-based team within the Kolling Institute have investigated how the brain’s own cannabis neurotransmitter systems control pain, and how this can support the treatment of pain. As a leader in the field, Chris has produced more than 130 publications, with the majority in leading journals. He has driven many large-scale, national projects including $5 million in NHMRC studies into the cannabinoid system and pain. In addition to his research, Chris has been a dedicated educator and mentor at the University of Sydney, contributing to both undergraduate and postgraduate courses. Colleague A/Professor Karin Aubrey said

Chris has mentored both senior and junior researchers, guiding 12 PhD and Masters’ students through their studies. “Chris’ influence extends far beyond the lab. Many of his mentees have gone on to become neuroscience researchers, medical doctors, and professionals across all levels of the health sector - and one became a winemaker,” she said. “His leadership style is defined by curiosity and skill. He not only has a deep academic understanding of his research area, but he also has the engineering skills to build a piece of bespoke equipment should you need it. “Chris gives people space to explore new ideas and develop their own projects. His leadership style is kind, human and scientifically rigorous - a combination that has left a lasting mark on those fortunate enough to work with him, including me.” Chris said he has been fortunate to have had such a diverse career. “It has been a wild and varied ride over the years, from engineering to various fields of the biomedical sciences, and finally pain research at Royal North Shore Hospital. I have been extremely lucky to have worked with many exceptional mentors and collaborators,” he said.

Dr Eddy Sokolaj, Kristen Anderson, Professor Chris Vaughan and Vanessa Mitchell

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