A Potential Cure for Alzheimer’s
A Promising New Vaccine in the Works
Around 5.8 million Americans suffer from Alzheimer’s. It affects 1 in 10 people over the age of 65. In recent years, a number of biotechs have attempted to develop vaccines to combat Alzheimer’s, but none have made it past early trial stages due to their problematic side effects such as brain swelling. Will a vaccine against Alzheimer’s ever be developed? While the answer to that question is still uncertain, one recent vaccine trial has shown some promise. United Neurosciences is currently developing drug UB-311, which made it through a phase 2a clinical study and will go on to a 2b study before moving onto the crucial third phase. If UB-311 clears the third phase of testing, it may be approved to be tested on large groups of patients. Phase 2a involved testing UB-311 on 42 patients presumably in the early stages of Alzheimer’s. They were divided into three groups, with one group receiving a placebo and the other two receiving the drug every couple months. Of those who received the drug, 96% showed signs of improved cognition and lower levels of beta-amyloid, a toxic plaque that builds up in Alzheimer’s patients’ brains.
on the theory that beta-amyloid buildup is a primary cause of Alzheimer’s, but recently, that assumption has been called into question. Other similar clinical trials that operate under that assumption have been halted by drug companies for that reason. Nevertheless, UB-311 has been received as a noteworthy development in the fight to end Alzheimer’s, and the results of the trial were presented at the 14th International Conference on Alzheimer’s and Parkinson’s Diseases last March. Even if a cure seems far off, the fact that there are people working tirelessly to eradicate the disease is reason enough to hope that the last days of Alzheimer’s are fast approaching.
A similar drug developed by scientists at the University of Texas Southwestern Medical Center also saw success. Their study also hinged
Trivia
Roasted Corn Salsa Inspired by Bon Appétit
Who was the first baseball player to have his number retired?
INGREDIENTS:
•
2 medium ears of corn, shucked
• 1 jalapeño or Fresno chile, seeded and thinly sliced • 1/2 red onion, diced • 1 large tomato, cored, seeded, and finely chopped • 1/4 bunch cilantro leaves, sliced • Juice of 1 lime • Kosher salt, to taste
A: Willie Mays B: Babe Ruth C: Lou Gehrig D: Cy Young
DIRECTIONS:
Submit your answers to email@jrphillipslaw.com
1. Heat a cast-iron skillet to high. Char corn, turning occasionally, for 10–14 minutes until kernels begin to blacken in spots. 2. Using a sharp knife, remove corn kernels from cobs and transfer to a large mixing bowl. 3. With a wooden spoon or potato masher, gently crush corn to release starch and juices. 4. Add jalapeño, onion, tomato, and cilantro. Mix to combine.
Correct answers will be entered into a drawing for an Amazon Gift Card.
Drawing will be held September 30,2019
5. Top with lime juice and season with salt. 6. Serve alongside your favorite tortilla chips.
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