Enzymatic flow electrolyser for the comproportionation of CO 2 and organic waste to formate Beverly Q. L. Low 1† , Santiago Rodríguez-Jiménez 1† , Andrea Rogolino 1 , Samuel J. Cobb 1‡ , Chen Han 1 , Guilherme Martins 2 , Inês A. C. Pereira 2 , Erwin Reisner 1 * 1 Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK, 2 Instituto de Tecnologia Química e Bioló gica Antó nio Xavier (ITQB NOVA), Universidade NOVA de Lisboa, Av. da República, 2780-157 Oeiras, Portugal † These authors contributed equally ‡ Current address: Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, UK Paired electrolysis enables the simultaneous coupling of CO 2 reduction reaction (CO 2 RR) with anodic waste valorisation to form two valuable products, but achieving selective, efficient and stable product formation remains a challenge. In this study, W-containing formate dehydrogenase (FDH) from Nitratidesulfovibrio vulgaris Hildenborough is immobilised onto an electrode made from carbon felt coated with porous TiO 2 and paired with commercial Ni foam to demonstrate the first enzymatic flow electrolyser for the simultaneous conversion of CO 2 and waste (plastic, food, and glycerol) to the single product formate. The enzymatic flow electrolyser achieved a combined Faradaic efficiency for both electrodes of almost 200% FE towards formate and can operate at an unprecedently low full-cell voltage of –1.5 V for 122 h. The aqueous formate produced in the semiartificial electrolyser was further utilised downstream as a C 1 building block in the photocatalytic hydrocarboxylation of alkenes, providing a path for the domino valorisation of CO 2 and waste toward bulk and fine chemical synthesis. References 1. Low, B. Q. L., et al., Manuscript in preparation 2. Bouwens, T., et al. , JACS, 2025 , 147, 13114-13119 3. Alektiar, S. N. and Wickens, Z. K., JACS , 2021 , 143 , 13022-13028
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