Accelerated discovery and characterization of nanoscale-covalent organic frameworks for photocatalytic water splitting Ziheng Xiao , Qi Jie Yeow, Sam Parkinson, Yushu Han, Seda Uyanik, Charlotte E. Boott, and Andrew I. Cooper, Materials Innovation Factory, and Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK Designing covalent organic frameworks (COFs) with suitable structures for photocatalysis applications is a time-consuming process. The development of automated and high-throughput methods can greatly increase the number of materials being synthesized and tested 1 . However, the synthesize process of bulk COFs usually involves high temperature and pressure, which is not easily achievable in an automated workflow. The emergence of nano-COFs synthesized by a simple surfactant-assisted process at room temperature and atmospheric pressure provides a chance for automated synthesis 2 . Here we report the high-throughput automated synthesis of a nano-COF library coupled with in situ computer vision-based analysis methods. Integrating this synthetic route with the automated workflow developed for photocatalytic water splitting performance test 3 , an end-to-end photocatalyst discovery system could be achieved. References 1. R. L. Greenaway, and K. E. Jelfs, Integrating Computational and Experimental Workflows for Accelerated Organic Materials Discovery. Adv Mater. 33, e2004831 (2021) 2. A. Cooper, W. Zhao, L. Luo, M. Cong, X. Liu, Z. Zhang, M. Bahri, B. Li, J. Yang, M. Yu, L. Liu, Y. Xia, N. Browning, W.-H. Zhu, and W. Zhang, Nanoscale Covalent Organic Frameworks for Enhanced Photocatalytic Hydrogen Production. Nat Commun.15, 6482(2024) 3. B. Burger, P. M. Maffettone, V. V. Gusev, C. M. Aitchison, Y. Bai, X. Wang, X. Li, B. M. Alston, B. Li, R. Clowes, N. Rankin, B. Harris, R. S. Sprick, and A. I. Cooper, A mobile robotic chemist. Nature. 583, 237-241 (2020)
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