Writing the Discussion Section
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Cluster analysis of all tumors grouped together could not differentiate between the groups. These data are illustrated in Fig. 1. However, there were several changes that were not common in the clusters of all tumor types, which may indicate differences in the molecular genetic pathways of tumor progression between different tumor types. In conclusion, we have used metaphase CGH to characterize the spectrum of somatic genetic events that occur in the development of epithelial ovarian cancer in tumors from BRCA1 and BRCA2 mutation carriers, familial non-BRCA1/2, and sporadic cases. In doing so, we have identified molecular genetic differences between these 4 tumor groups that suggest there are different mechanisms for tumor development, which may influence the phenotype and clinical outcome of ovarian cancers.
Adapted from the well-written Discussion in Ramus SJ et al. BRCA1/2 mutation status influences somatic genetic progression in inherited and sporadic epithelial ovarian cancer cases. Cancer Res 63:417 – 423, 2003.
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