Brain - Improved brain function and protection from degeneration of the nervous system, especially of neurons in the brain Vasculature (blood vessels) - Increased formation of new blood vessels and improved blood flow Liver - Improved liver function and reduced fatty liver disease Muscle - Reduced atrophy, enhanced mitochondrial function (energy production) , increased insulin sensitivity and increased physical activity Pancreas - Increased insulin secretion and reduced inflammation Fat tissue - Reduced dyslipidemia (defined as elevated total or low-density lipoprotein cholesterol levels, or low levels of high-density lipoprotein cholesterol) and prevention of insulin resistance Inflammageing (age-related increase in the levels of pro-inflammatory markers in blood and tissues) - Reduced inflammation and improved immune cell function Strategies that boost NAD+ levels include lifestyle changes, such as increasing exercise, reducing number of calories consumed, eating a healthy diet and following a consistent daily pattern of healthy sleeping habits and mealtimes. Another approach is the use of inhibitors or activators to boost NAD+ production and the use of dietary supplements. [33] Potential health benefits of boosting NAD+ levels vary by body tissue and include: [33-35] Health effects of reduced nicotinamide adenine dinucleotide (NADH) While nicotinamide adenine dinucleotide (NAD+) or reduced nicotinamide adenine dinucleotide (NADH) is an essential metabolic cofactor that is central to energy metabolism, NAD+ concentrations in cells decline with aging and is linked to numerous aging-associated diseases, including loss of muscle tissue and frailty, metabolic disease such as high blood sugar, and cognitive decline. [33] Many of these diseases may be slowed down by replenishing NAD+ levels and therefore, targeting NAD+ levels has emerged as a potential therapeutic approach to moderate ageing-related disease, and extend the human healthspan and lifespan.
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