Does NADH supplementation alter outcomes? The majority of the current data are from animal studies where increasing NAD levels has been shown to improve mitochondrial (location where energy production occurs) function, waste disposal , and DNA repair while decreasing oxidative stress, inflammation, and aging. [36] In a small study of patients with Chronic Fatigue Syndrome, NADH was shown to reduce fatigue. [37] In disorders of brain aging such as Parkinson’s Disease, NADH supplementation improved disabilities related to movement. [30, 36] Similarly, NADH may improve cognitive function. [30, 36] Several clinical studies have shown promising results but others have shown little or no benefit, suggesting that benefits may be highest in those with low tissue NAD+ concentration at baseline. In a recent, 10-week, randomized, placebo-controlled, double-blind study (highest quality study) , increasing NAD+ levels improved skeletal muscle insulin signaling and sensitivity in postmenopausal prediabetic women who were overweight or obese. [38] An addition benefit was that genes related to muscle remodeling and regeneration were also up-regulated. These findings demonstrate the safety and effectiveness of NAD+ supplementation, although additional research is needed. What is the suggested dose of NADH? Although higher doses have been safely administered, common dosing ranges from 5-20 milligrams per day.
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