Differential Gene Expression analysis: Recurrent vs Primary tumors
• Functional Enrichment analysis: Gene Set Enrichment
• 31 differentially expressed gene identified (P adj < 0.05, FoldChange > 2)
Higher Expression in Primary Tumors : • LHCGR and INSL3 - genes involved in normal ovarian sex cord hormonal signaling Higher Expression in Recurrent Tumors: • NELL2 , GDF6 , and IL1RL1 - in some cancer types increases expression of these genes were associated with increased metastasis and decreased survival rate • CYP19A1 (aromatase) expression may be closely linked to aGCT pathogenesis and progression
Primarily immune-related and hormone-regulated gene sets expression was increased in recurrent tumors
Eleonora Khlebus eykhlebus@mdanderson.org
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