Comparative tumor microenvironment analysis
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Tumor microenvironment analysis
• Tumor microenvironment in silico cytometry
Higher fractions in Recurrent tumors Lower fractions in Recurrent tumors
CIBERSORTx
Modified from Newman et al. (2019) Nat Biotech.
Conclusions:
§ Tumor microenvironment composition is significantly different between primary and recurrent aGCTs • Recurrent tumors have increased myeloid fraction and reduced prevalence of stromal cells what can promote tumor progression § Expression of genes involved in ovarian hormone signaling was identified as significantly altered in recurrences • Changes in hormonal signaling pathways may underpin aGCT recurrence
Financial support: This work was supported by grants from the Cancer Prevention and Research Institute of Texas (CPRIT) to R.T.H. (RR200045) and P.A.F. (R1205). R.T.H. is supported by the Jennifer “Jenny” Song Fund for Granulosa Cell Tumor Research. The University of Texas MD Anderson Cancer Center Multidisciplinary Gynecologic Cancer Tumor Bank is supported in part by NIH P50CA83639 SPORE in Ovarian Cancer. The authors declare no potential conflicts of interest.
Eleonora Khlebus eykhlebus@mdanderson.org
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