JOURNAL OF THE LOUISIANA STATE MEDICAL SOCIETY
Figure 3: Tumor composed of oligodendroglia-like cells in a microcystic background (hematoxylin-eosin, original magnifications ×400 [A]). At higher magnification (B) the characteristic oligodendroglia-like cells with uniform round nuclei in a fibrillary background (hematoxylin-eosin, original magnifications ×2000). The tumor showed characteristic positivity for immunohistochemical stains, (C) Glial fibrillary acidic protein, (D) Synaptophysin and (E) Neurofilament (original magnifications x2000).
Still, final diagnosis solely depends upon histopathological analysis. Histologically, DNETs resemble other ganglioneural tumors because of the presence of oligodendroglial like cells (OLC). A multinodular architecture is characteristic especially in cortical locations. Small, round OLC cells along with floating neurons in a gelatinous matrix form a microcystic or alveolar pattern. 11 On immunohistochemistry staining, the OLCs are positive for S-100 and Oligo-2 protein. They also express other neuronal markers like synaptophysin, Neu N, NSE and MAP2. 11 DNETs in theseptumpellucidumdonot differmuchhistologically from cortical DNETS; however, occasional irregularity from the classical pattern has been observed. Firstly, the characteristic multinodular pattern is less frequently observed in DNETs of septum pellucidum. 6,23 Secondly, we observed a less cellular growth in our specimen. Similar to Baisden et al., 6 we also noted single OLCs with a uniform round nuclei floating in a fibrillary background. In 50% of patients in Baisden et al series, synaptophysin positivity was noted on immunohistochemical
• Lipoma • Hamartoma • Cavernous Hemangioma • Vascular malformation with hemorrhage
NON-NEOPLASTIC
• Cysticercosis • Colloid cyst
• Central Neurocytoma • Subependymoma • Subpendymal giant cell astrocytoma • Low grade astrocytoma • Pilocytic astrocytoma • Oligodendroglioma • Ganglioglioma • Dysembroplastic neuroepithelial tumor
NEOPLASTIC
Table 1. Differential diagnosis of lesions in the septum pellucidum
J La State Med Soc VOL 169 SEPTEMBER/OCTOBER 2017 125 J La State Med Soc VOL 169 JULY/AUGUST
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