J-LSMS 2014 | Annual Archive

invasive aspergillosis undiagnosed until the time of au- topsy underscores the importance of being mindful of the diagnosis of Aspergillus infections not only in the classically immunodeficient patients but also in the presumably im- munocompetent individuals. It is likely that in the current case, the patient’s determinants of increased risk included alcoholism and liver failure due to established cirrhosis. ACKNOWLEDGEMENTS The authors would like to gratefully acknowledge the support of the Orleans Parish Coroner’s Office: Dr. Frank Minyard and Chief Investigator JohnGagliano for providing the case material for this report. REFERENCES 1. Latge JP. Aspergillus fumigatus and Aspergillosis. ClinMicrobiol Rev . 1999;12(2):310-350. 2. Kousha M, Tadi R, Soubani AO. Pulmonary Aspergillosis: a Clinical Review. Eur Respir Rev . 2011;20:156-174. 3. Rankin N. Disseminated Aspergillosis andMoniliasis Associated with Agranulocytosis and Antibiotic Therapy. Br Med J . 1953;183:918-9. 4. Fraser DW, Ward JL, Ajello L, et al. Aspergillosis and Other Systemic Mycoses. The Growing Problem. JAMA . 1979;242:1631- 5. 5. Denning DW. Invasive Aspergillosis. Clin Infect Dis . 1998;26:781- 803.

6. Lin SJ, Schranz J, Teutsch SM. Aspergillosis Case Fatality Rate: Systematic Review of the Literature. Clin Infect Dis . 2001;32:358- 66. 7. Vandewoude KH, Blot SI, Benoit D et al. Invasive Aspergillosis in Critically Ill Patients: Attributable Mortality and Excess in Length of ICU Stay and Ventilator Dependence. J Hosp Infect . 2004;56:269-276. 8. Kalokhe AS, Rouphael N, El Chami MF et al. Aspergillus Endocarditis: a Reviewof the Literature. Int J Infect Dis . 2010;1040- 1047. 9. Aleksenko A, Gyasi RK. Disseminated Invasive Aspergillosis. Ghana Med J . 2006;40(2)69-72. 10. McNeil MN, Nash SL, Hajjeh RA, et al. Trends In Mortality Due to Invasive Mycotic Diseases in the United States, 1980-1997. Clin Infect Dis . 2001;33:641-647. 11. Denning DW. Therapeutic Outcome in Invasive Aspergillosis. Clin Infect Dis 1996;23:608-15. 12. Kourkoumpetis TK, Desalermos A, Muhammed M et al. Central Nervous System Aspergillosis. Medicine 2012;91:328-336.

In the Department of Pathology at Louisiana State University School of Medicine in New Orleans, Dr. McGoey is an Associate Professor of Pathology and Residency Program Director, and Dr. Newman is a Professor of Pathology and Director of the Autopsy Service.

J La State Med Soc VOL 166 March/April 2014 95

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