Fluorescent and bioluminescent probes for imaging and diagnostics Kai Johnsson 1,2 1 Max Planck Institute for Medical Research, Germany 2 EPFL Lausanne, Institute of Chemical Sciences and Engineering, Switzerland; E-mail: johnsson@mr.mpg.de The topic of my presentation will be how a combination of protein engineering and synthetic chemistry can be exploited to generate fluorescent and bioluminescent probes for live-cell imaging. Specifically, I will review our attempts to introduce new fluorescent dyes and sensor proteins that permit to visualize biochemical activities in living cells with high spatial and temporal resolution. I will also discuss how these sensor proteins can be utilized for point-of-care therapeutic drug monitoring.
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© The Author(s), 2023
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