The Clevenger lab at the HudsonAlpha Institute for Biotechnology, a nonprofit institute dedicated to developing and applying scientific advances in agriculture through genomics, has developed a computational tool to help identify genetic factors to select for beneficial agricultural traits. Our mission is to help you create a more robust and sustainable agricultural landscape for your crops. Finding Beneficial Traits for Improving Crops Bringing Costs Down While Keeping Accuracy High Khufu’s analysis platform maps genes by using low pass whole genome sequencing that was specifically designed to be highly accurate in complex plant genomes. Current traditional high throughput genotyping technologies utilize fixed marker arrays or only sample small portions of the full genome to be cost efficient. However, Khufu’s accuracy allows the use of low coverage whole genome sequencing to access the entire genome and remain cost effective. Practically, this means that instead of checking for one or a few markers per sample, Khufu will deliver all markers of interest at once and has the following uses: s High resolution trait mapping – linking genotype to phenotype for gene identification and marker development s High throughput genotyping – genome-wide markers for genomics-assisted selection, identify contamination issues, quality assurance, and diversity analysis
With the use of Khufu and low coverage sequencing of bulks, QTL-seq is now rapid, economical, and likely to identify functional SNPs, thus game-changing for plant breeders and molecular geneticists.
Peggy Ozias-Atkins Professor and Director Institute of Plant Breeding, Genetics & Genomics University of Georgia —
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