Magnetically - triggered protein release using iron oxide core - PNIPMAM shell nanoparticles Rajat Sharma , Victor Chechik University of York, UK Superparamagnetic iron oxide nanoparticles (IONPs) are well known for biomedical applications due to their inherent magnetic behaviour and biocompatibility 1 . IONPs can be heated by an alternating current magnetic field (ACMF) and the heat generated can be used in magnetic hyperthermia and drug delivery applications. IONPs functionalised with temperature-responsive polymers present a potential combination for drug delivery and release 2,3 . Poly(N-isopropylmethacrylamide) (PNIPMAM) is such a polymer that is soluble in water below its lower critical solution temperature (LCST ~ 45˚C) but it collapses and becomes insoluble above LCST. Here, the synthesis of Fe 3 O 4 core-PNIPMAM shell nanoparticles is reported along with their potential use as a protein carrier in-situ (Figure 1). Present study could be useful in understanding protein-IONPs interactions which is an essential criterion in designing any protein carrying cargo.
Figure 1: Schematic illustration of the protein delivery from the Fe 3 O 4 core-PNIPMAM shell nanoparticles using magnetic heating as a trigger. References 1. A. Hervault and N. T. K. Thanh, Nanoscale , 2014, 6 , 11553-11573. 2. S. Kurzhals, R. Zirbs and E. Reimhult, ACS Appl. Mater. Inter. , 2015, 7 , 19342-19352. 3. M. Walker, I. Will, A. Pratt, V. Chechik, P. Genever and D. Ungar, ACS Appl. Nano Mater ., 2020, 3 , 5008-5013
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