Developing stepwise catalysis for the construction of functional fluorinated molecules via a bridging nitrogen ruthenium precursor Aidan Carr, Dr John Slattery, Dr Jaosn Lynam University of York, UK Fluorinated molecules play a significant role pharmaceutical, agrochemical and plastics industry. 1,2,3 We have previously reported a new stoicheometric method for synthesis of difluoroalkenes via a ruthenium half-sandwich complex using outer sphere electrophilic fluorination. 4,5 Herein we report our current development of this process into a step-wise catalytic cycle. Work has been done to move away from the [CpRu(dppe)Cl] that requires activation to a reactive bridging nitrogen species [{CpRu(dppe)} 2 -µ-1,2-N 2 ][OTf] 2 (OTf = SO 3 CF 3 ). This compound is air stable as a solid but will readily react with a range of ligands in solution-phase. Characterisation of this bridiging nitrogen species has been done and found that the solution-phase composition is a complicated mix of exchanging ruthenium centres. With this new reactive precursor we have developed a route to fluorovinylidenes in a one pot and one solvent system. References 1. B. M. Johnson, Y. Z. Shu, X. Zhuo and N. A. Meanwell, J. Med. Chem., 2020, 63, 6315–6386. 2. P. Shah and A. D. Westwell, J. Enzyme Inhib. Med. Chem., 2007, 22, 527–540. 3. D. R. Silva, J. K. Daré and M. P. Freitas, Beilstein J. Org. Chem., 2020, 16, 2469–2476. 4. L. M. Milner, L. M. Hall, N. E. Pridmore, M. K. Skeats, A. C. Whitwood, J. M. Lynam and J. M. Slattery, Dalt. Trans., 2016, 45, 1717–1726. 5. L. M. Hall, L. M. Milner, S. J. Hart, A. C. Whitwood, J. M. Lynam and J. M. Slattery, Dalt. Trans., 2019, 48, 17655–17659.
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