Ardmac Pharma Solutions Oct 2023

We’ve got News Ardmac Pharma Solutions Quarterly Newsletter October 2023

04 CASE STUDIES: UNIVERSITY OF CARDIFF HSE GERMFREE BIOGO® MOBILE CGMP CLEANROOM CONFIDENTIAL MODULAR PROJECT

Hello from Ardmac,

10 GERMFREE’S INNOVATIVE MODULAR CLEANROOM SOLUTION ADDRESSES SEVERAL KEY CHALLENGES

Welcome to our quarterly newsletter, where we will keep you up to date with current developments and thinking within our Pharma Business Unit. In this issue we are proud to share some recent case studies we have been working on, including Cardiff University, our mobile CGMP cleanroom and take a look at our modular offerings. We will also share a series of blogs surrounding the new Annex1 guidelines. Finally we take a look back to a very successful Cycle for Hope 2023. Thank you to all who supported us on the day. We hope you enjoy reading and if there is anything you’d like to see in future issues, please let us know.

12 THE CHALLENGE AND DANGER OF CLASSIFICATION AT 5 MICRON PARTICLE SIZE AND GREATER IN ANNEX 1

14 WHAT IS YOUR GMP CLEANROOM CLEANROOM CONTAMINATION CONTROL STRATEGY (CCS)?

16 WHAT HAPPENED TO OUR AIR CHANGE RATE TABLE IN THE NEW ISO 14644-4:2022?

18 PRECISION CLEANROOM CONSTRUCTION

20 DOES THE USE OF INTEGRATED PROJECT DELIVERY (IPD) REMOVE BARRIERS TO LEAN CONSTRUCTION AND BIM ADOPTION?

22 ARDMAC OUT AND ABOUT

24 ARDMAC CYCLE FOR HOPE 2023

Reach out to George Walker Business Development Director george.walker@ardmac.com +353 (0) 86 805 1723

Reach out to Enda Murphy MD Cleanrooms enda.murphy@ardmac.com +353 (0) 85 888 8340

Reach out to Dermot McKenna Associate Director Business Development dermot.mckenna@ardmac.com +353 (0) 86 813 5475

Reach out to Mark McCullagh Operations Director mark.mccullagh@ardmac.com +353 (0) 86 812 7170

Reach out to Mark Seymour Regional Manager UK mark.seymour@ardmac.com +44 (0) 1 7785 324 599

University of Cardiff

Ardmac were employed as the Cleanroom Contractor for University of Cardiff. The package consisted of the supply, installation and commissioning of the cleanroom systems for the ICS Cleanroom.

This consisted of: •

ceilings, including lights and blank pans

• • • • •

walls and doors raised access floor gowning areas

fan filter units

walk-on plenum grid system

• plenum dividers underfloor between clean bays • equipment chases • ducted ULPA filter modules

Ardmac were responsible for the detailed surveying of the relevant part of the existing building and the setting out of construction to suit site conditions. The detailed development of the design for the cleanroom fabric components (walls, floor, ceiling, etc.) was also part of the scope. This included working closely with Advanced Engineering Design during the stage 4A, through C4 detailed design.

This project was designed to a level of detail 300 (LOD 300) in the modelling process using Building Information Modelling (BIM). At LOD 300, the 3D models include comprehensive geometric representations of building components with accurate sizes, shapes, and locations. This level focuses on elements such as walls, doors, windows, and other major building systems, providing sufficient detail for clash detection and coordination among different trades. LOD 300 models also include relevant information like specifications, material types, and quantities, making them valuable for construction planning, cost estimation, and early-stage analysis.

HSE Germfree bioGO® Mobile cGMP Cleanroom

The HSE contracted Ardmac to provide our mobile temporary cleanroom facility to support their existing Pharmacy manufacturing capacity on the Cork University Hospital Campus. Our solution was key to the fast track delivery model required for this project. The mobile unit was integrated into a larger modular facility where the GMP mobile unit was integral to the process required.

The unit was design and commissioned to meet ISO 8 and comprises of the following:

ISO 8 Main Lab ISO 8 Preparation Room ISO 8 Ante Room CNC internal Lobby

Also an additional Pass Thru was integrated into the external fabric of the unit to allow for sperate Material flow to the wider facility.

Our latest modular delivery

Our most recent modular project consisting of thirteen units has been successfully delivered and positioned. Measuring just over 18 meters in length, 5.4 meters in width, and standing at a height of 4 meters, the unit carries an impressive weight of 40 tonnes. The dedicated Ardmac modular and design team, along with our supply chain partners, have worked tirelessly with early morning starts to guarantee that these deliveries did not disrupt the daily commute of others. We extend our congratulations to the entire team for their focused efforts, and sincere thanks to all involved in this achievement.

germfree’s innovative modular cleanroom solution addresses several key challenges On a recent pharmaceutical project for a global client, Germfree addressed several key challenges with our innovative modular cleanroom solution. These challenges included speed to market, geography and localisation challenges and logistics and transportation.

Parallel Construction

Geography and Localisation Challenges

Speed to market is a traditional challenge for pharmaceutical companies, however modular addresses this challenge by allowing “parallel construction” to take place, where the shell building, which houses the cleanrooms, is constructed at the same time as the cleanrooms. On a traditional project, the construction and weathering of the shell building must be completed ahead of the commencement of the cleanroom construction – one process follows the other. However, with our modular solution, the manufacturing of the modular cleanrooms can commence ahead of the shell building construction. This innovation on the traditional build sequence of pharmaceutical facilities reduces the overall construction timeframe for the project which in turn can reduce the time to market for the lifesaving products manufactured within these facilities. This helps to ensure that the products reach patients as quickly as possible.

Various challenges can arise when trying to deliver high-tech facilities in new and remote jurisdictions. Issues can arise in countries relating to availability of skilled labour, local infrastructure including telecommunication networks, transportation systems, security of power supply, security, and even availability of necessary construction materials. All these issues can reduce the feasibility of constructing high value facilities by traditional means in certain countries. However, with our modular cleanroom solutions, several of these risks are mitigated with up to 98% of the facility being constructed off site in a controlled manufacturing facility by skilled, experienced construction professionals. Our modular cleanrooms are designed based on “plug and play” principles for all MEP services, meaning that once the modules are installed in the shell building, they simply require a connection to the main building utilities. the modular cleanroom facility undergoes a comprehensive Client-witnessed FAT (Factory Acceptance Test) and commissioning process before being transported to their destination which helps to reduce programme involved in making the facility operational once assembled in its final location.

Logistics and Transportation

Logistics and transportation are a key consideration when deploying modular solutions. On a recent pharmaceutical project for a global client, which saw cleanroom containers flown to Africa, the logistics and transportation needed to be considered during the design phase. This removed the need for special transport arrangements which in turn reduced cost and programme.

For more information on Germfree click here www.germfree.ie/germfree-in-europe

Modular Project on site

Plant Module above ceiling level

Modules loading

Modules unloading in Rwanda

The Challenge and Danger of Classification at 5 Micron Particle Size and Greater in Annex 1 The presence of 5 micron and greater particles in Cleanrooms and in particular ISO 5 UDAF environments has been a source of much discussion and contention over many decades. Essentially the arguments have been over the significance and importance of the measurement of 5 micron particles as indicators of unwanted and adverse microbiological contamination, affecting product quality and ultimately patient safety. In a nutshell this blog will bring out the subtle but important differences between “Classification” and “Monitoring”. Hopefully this will give you the clarity and justification to avoid getting caught out by the law of unintended consequences and follow good science from ISO/TC 209 and the ISO 14644 family of cleanroom standards, referred to in the new Annex 1.

The bottom line is the ISO/TC 209 based scientific guidance is that 5 micron particle size measurements should not be used for formal Classification at ISO 5. Why? because it does not comply with ISO 14644- 1. However, we should not ignore the 5 micron particle size during qualification. We should use the information in an appropriate way during testing, both At Rest and in Simulated Operations. Why? Because the 5 micron particle size is required for measurement and assessment during real-time Monitoring and continuously for ISO 5 and Grade A. Of even more importance is the “Law of Unintended consequences”! In attempting to classify at 5 micron size and greater the danger is you get hooked on Clause 5.9 dealing with

airborne particle counters, where the simplistic guidance is tube lengths should typically be less than 1m (unless justified) and the number of bends should be minimised. So, if you choose to classify at 5 micron size channel size, then “This is the rock you perish upon” Why? because in ISO 5 UDAF environments (e.g. RABS and Isolators) it is not possible to meet Clause 5.9 in every respect, and at every sampling location. There is a new TR (Technical Report) coming from ISO/TC 209 and expected in 2023, that gives best practice guidance on this subject and the correct application of ISO 14644-1 for classification when measuring larger particles, i.e. 5 microns and greater, and when monitoring applying ISO 14644- 2.

Clause 5.9 does not take into account that at 0.5 micron measurements tube length and bends is less important than at 5 microns! This brings us right back to notes d) and e) in Table 1 of ISO 124644-1:2015. During routine monitoring trending is the most important consideration and therefore you have more wriggle room in terms of justification of longer tube lengths and more bends due to configuration challenges, than you have during Classification. Now for the longer version, if we want to better understand the underlying issues involved. We need to take a deeper dive into the detail and go back to the basics and the challenge of measuring microbiological contamination and assessing the risks in the cleanroom environment to product quality and ultimately patient safety. This arises because we have the common use of laser airborne particle counters (LSAPC) that give real-time instantaneous results after 1 minute, but of the total number of particles, with no discrimination between inert and microbiologically active particles or micro- organisms. LSAPCs have been used for cleanroom classification for decades but have some limitations at larger particle sizes, when remotely used, e.g. in ISO 5 UDAF RABS and Isolator Life Science applications. Until the advent of BFPCs (BioFluorescent Particle Counters) we relied on traditional indirect sampling based methods using CFUs (Colony Forming Units) rather than AFUs (Auto Fluorescing Units). Unfortunately CFU based

methods rely on growth and take multiples of days to show evidence of microbiological presence. This is why microbiological contamination is commonly referred to as the “Unseen Enemy” or “Bad Bugs”. In the absence of real-time viable particle counters conventional wisdom in Europe was look carefully at 5 micron and greater particle sizes as they reflected micro-organisms or microbe carrying particles (typically around the 25 micron size). Although there is no clear explanation or history, critical cleanroom regulatory guidance are different in the US and the European Union (EU). Requirements for cleanrooms are among the most critical issues of Good Manufacturing Practices (GMPs), but differences between expert opinions among regulators in the US and EU are responsible for this difference, creating confusion and misunderstandings. In the US the concentration is on 0.5 micron particles but in Europe the requirement was to measure at both 0.5 and 5 micron particle sizes.

Click here to continue reading article www.ardmac.com/the-challenge-and-danger-of-classification-at-5-micron-particle-size-and-greater-in-annex-1/

What is your GMP Cleanroom Cleanroom Contamination Control Strategy (CCS)?

Imagine a scenario where your organization is gearing up for a regulatory audit and you have been tasked with supporting their preparation of a Cleanroom Contamination Control Strategy (CCS).

The CCS outlines the key decisions and scientific rationales for contamination control, and is based on a detailed understanding of the process, contamination risks/hazards and contamination source strengths, i.e. the application of QRM. The CCS is focused on where the product or process is exposed and at risk, critical control points (CCPs) and mitigation controls, applying the best available technologies and in an integrated and holistic manner. The CCS will address all aspects of the control measures, (Physical, Organisational and Procedural) under the following fundamental categories:

It could be a separate document file, like a Site Master File (SMF) OR Quality Management System (QMS), while others, including myself, take the view that the CCS is a high-level document, is not expected to be a Bible but does reference other parts of the SMF and QMS, thereby avoiding unnecessary duplication. It is important to demonstrate to the auditor that you understand the critical quality attributes (CQAs), the critical process parameters (CPPs), the critical control points (CCPs) in the environment, the hazards at each risk, the consequences and what we need to do to protect our patient.

•

Engineering Controls

• People and Material controls, Gowning and Behaviour • Ongoing Cleaning & Disinfection

There are many views of what a CCS should look like.

Click here to continue reading article https://www.ardmac.com/annex1-gmp-cleanroom-cleanroom-contamination-control-strategy-ccs/

What happened to our Air Change Rate Table in the new ISO 14644-4:2022? Rethinking Cleanroom Design The new ISO 14644-4 was published in November of last year and addresses design, construction, and start-up of Cleanrooms. But why has the Air Change Rate table from Annex B.2 disappeared? Well, because no one size fits all; the old table led to over-design in many cases and a lack of focus on understanding the process and contamination risks. The new and revised Annex 1 places the focus on QRM (Quality Risk Management) and CCS (Contamination Control Strategy) instead. The ISO/TC 209 working group, composed of subject matter experts from nearly 20 countries (including Ireland, UK, France, Germany, Switzerland, The Netherlands, Italy, Sweden, Norway, Denmark, Romania, Russia, China, Japan, Australia, Philippines, Korea, Brazil, and the USA) decided there was a better way – good engineering practice (GEP) and good science would prevail!

The Evolution of ISO 14644 Standards

Back in the late 1990s when the first version (2001) was being developed the experts at the time agreed, that as part of the “first generation” of the new ISO 14644 standard series of dashes, they would include some general guidance. They put the Air Change Rate table in the Informative Annex purely as a backup plan, to be used in the event of no other information being available. Unfortunately, lots of people, both users and designers adopted the Air Change Rate table, which was often cross referenced in the URS. The need for compliance in a heavily regulated industry paved the way for this approach and this became the norm over time.

To make matters worse, from a Life Science perspective the language and guidance was driven by the Microelectronics Industry, which at the time was operating at very low particle thresholds and was heavily reliant on unidirectional airflows and high concentrations of HEPA filtered air. So, when we look at ISO 7 and ISO 8 in the context of Life Science and Sterile Medicines in Annex 1, terms like “Service Zones” and “Surface Treatment” meant nothing.

Guide to Good Manufacturing Practice

The rules governing medicinal products in the European Union were issued by the EU around the same time as ISO 14644 was first issued, and EU Pharmacopoeia became the benchmark for the manufacture of medicinal products. The directive laying down principles and guidelines of good manufacturing practice (GMP) for medicinal products for human use (Directive 91/356/EEC) was adopted by the Commission in 1991. Detailed guidelines in accordance with those principles are published in the Guide to Good Manufacturing Practice (EudraLex) which is used in assessing applications for Manufacturing Authorisations and as a basis for inspection of manufacturers of medicinal products by the Regulator. For the manufacture of sterile medicinal products there are 4 grades of clean ware specified

Areas, Grades A, B, C, & D.

In the original ISO 14644-4:2001 the guidance given for the maximum permitted number of particles in the “At Rest” condition corresponded approximately to the US Federal Standard 209E and the ISO 14644 classifications as follows: Grades A and B correspond with class 100, M 3.5, ISO5 Grade C with class 10.000, M 5.5, ISO 7 Grade D with class 100.000, M6.5, ISO 8 Hence Grade A, B, C and D facilities for the manufacture of medicinal products became inextricably linked to ISO 14644 cleanroom classifications and unfortunately tagged with ACR (Air Change Rates).

Click here to continue reading article https://www.ardmac.com/what-happened-to-our-air- change-rate-table-in-the-new-iso-14644-42022/

Precision Cleanroom Construction

Ardmac is an international construction specialist that delivers complex high value workspaces and technical environments, with precision. For more than 40 years, Ardmac has been one of the largest providers of microelectronics Cleanrooms, mini-environments and tool install packages throughout Europe. We have worked with the top wafer fab and microelectronics manufacturers, along with their key vendor supply chain partners during this time.

Safe and precision controlled particle free clean environment

As consumers, we demand ever increasing performance, coupled with reliability. This creates a challenge of speed to market, then to volume and finally flexibility and change. We leverage technology and industry partners in the delivery of the complete solution, allowing our customers to focus on their core business. Our objective is to create a safe and precision-controlled particle free clean environment that exceeds industry requirements of low off-gassing, vibration sensitivity and compatibility. Ardmac pride ourselves on understanding the unique demands of the Microelectronics and related Advanced Technology Facilities (ATF), as well as their critical supply chain vendors and partners. Nothing less is acceptable for today’s fast evolving manufacturing challenges and mission critical facilities.

Ownership – Responsibility and Accountability

We take ownership of the solution and accountability for the performance of the cleanroom. Airborne Particle concentrations Vibration Room pressurisation Temperature Humidity Containment Illumination Ionisation

Our modular approach and solutions are designed to be flexible, scalable and repurposed. In particular where these are vendor support cleanrooms they can be relocated and are scalable. Early engagement is key to successful outcomes for end users and our integrated approach will ensure alignment on the understanding of user needs and performance requirements, along with environmental and safety compliance. Ardmac uses BIM tools extensively to create a Digital Twin from concept through to Handover and ongoing FM. This is a journey from VR to AR to a Digital Twin. At Ardmac we Work Smart, meaning we combine the three pillars of Lean construction, BIM, and Field Management. This comprehensive approach aims to “design out” all forms of waste from projects, optimizing processes and driving efficiency. We pride ourselves on working within wider teams, collaborating in a federated design world, and coordinating with like-minded contractors and tool vendors in an open communication platform – using Audio Visual & Augment Reality tools to create a “single source of truth” with embedded information to integrate with supply chain vendors.

Standard spans designed and optimised around manufacturing and process requirements. Revit modelled repeatable and interchangeable solutions. Columns, Beams, Brackets, fixings are common across designs Revit families developed. Integrated structural calculations. Bracing – Temporary or permanent – Enclosed or concealed. Anti-vibration design with specialised suspension and connections.

One Stop Shop

Where temporary manufacturing support buildings are required on site and/or for their supply chain, including vendor tool support facilities, we offer single source fast track solutions that combine our Cleanroom turnkey expertise together with a full construction service to build a complete solution. We can provide and support all the requirements of the project ensuring full compliance across all aspects of the facility build.

See more here: https://www.ardmac.com/micro-electronics/

Partnerships

We select solutions to accommodate client requirements within the cleanroom including the support of AMHS systems. Known for our adaptable, efficient designs depending on cleanroom classification, pre-engineered with long span solutions for optimal facility layouts, the Ardmac structural solutions range includes:

Does the use of Integrated Project Delivery (IPD) remove barriers to Lean Construction and BIM adoption?

by Fergus Nugent, Associate Director of Project Management

Issues surrounding the lack of productivity in the construction industry are well documented. The benefits of lean construction (LC) and Building Information Modelling (BIM) are extensively researched, yet the widespread adoption of both concepts has been slow across the construction industry. After working on several Integrated Project Delivery (IPD) projects, the author decided to research the use of BIM, LC and IPD using a mixture of literature review and interviews with industry experts. This article is a summary of the research project including the key findings. This study began by explaining the issues with productivity in the construction industry. By conducting a detailed literature review, the author then discussed the benefits of LC and BIM adoption followed by highlighting the synergies between both initiatives as shown in the research of Sacks, Dave and Eastman, among other renowned subject matter experts. The literature review revealed that IPD projects displayed elevated levels of success through the

implementation of LC and BIM while also revealing that the uptake of LC and BIM across Ireland and the UK is still low. Objectives: 1. To analyse where there are synergies between LC and BIM. 2. To provide an extensive review of academic sources to demonstrate the improved efficiencies observed by construction companies using LC, BIM, or both. 3. To review the published literature for any challenges or barriers to the widespread implementation of LC and BIM in Ireland and the UK. 4. To engage with key individuals working on two projects utilising IPD to understand if those projects have overcome the barriers identified in objective 3. 5: To produce a decisive conclusion by combining both secondary and primary research sources.

Key Findings The results highlighted that both projects were extraordinarily challenging, but that IPD has been a resounding success. One project director stated that Project A was the best-managed project they had seen. Even with success, there were still challenges on both projects: schedule, unlearning old habits, upskilling project teams, and establishing trust, were all identified by multiple stakeholders. Reasons for the successes highlighted are: planning and shared resources, healthy profit margins and an overall sense of teamwork and collaboration that was higher than most traditionally managed projects. It is also interesting to note that Project A showed a higher level of LC implementation, while Project B displayed a higher level of BIM implementation. Segmented Industry It is no coincidence that all partners involved in the IPD on both projects had previous established relationships. For IPD to become more popular, companies need to build relationships and experience positive results, not just with clients but with other organisations. Key relationships with other companies will become crucial for organisations to be selected as IPD partners. Silo Mentalities Both projects had a CDE (Common Data Environment) in place to streamline the flow of information, however on both projects, the leadership team also met regularly to communicate; this was highlighted as the critical factor in eliminating traditional silo mentalities. Project B also had a communication charter which explained when, and how to communicate. This established a culture of respect which is crucial to effective teamwork and collaboration.

top construction talent. Not every project will have this advantage. It is important to note that not all essential personnel were experienced in LC and BIM. It is not always possible to find suitable personnel within the required time. These companies selected experienced team members and provided all necessary technical training. Recommendations The public sector should take the lessons learned from these projects and implement IPD as a standard approach for construction projects in Ireland and the UK. This would require commitment from the industry to deliver a standard IPD framework with suggested contracts and best practice guidelines. If this became the norm in the public sector, the private sector would be more likely to widely adopt IPD. LC and BIM organisations should collaborate to promote the improved results from IPD. Companies who are interested in improving productivity should contact government agencies or LC and BIM organisations for funding, which is available through multiple sources in Ireland and the UK. These organisations could use this research as a framework to design LC and BIM training courses. A recommendation for future research would be the expansion of the developed methodology across a larger sample size. Another suggestion would be to generate a detailed case study on each project to provide an insight into the challenges and successes of each project and provide a benchmark for other organisations to follow in the future.

Skills Shortage & Education The prestige of both projects, the reputation of the clients and the scale of the projects combined to attract

#ArdmacEvents Germfree Roadshow 2023

Germfree’s Associate Director George Walker had a fantastic time at Advanced Therapies in Miami with our partners Germfree US. The event, run by Phacilitate brought together industry leaders and showcased interactive demonstrations and commercial- scale manufacturing, with Germfree showcasing our mobile cGMP mobile cleanroom. #ArdmacEvents annex 1 impact on GMP cleanrooms Dermot Mc Kenna presented at the Irish Cleanroom Society’s Annex 1 roadshow on the 31st of Jan. Dermot covered cleanroom product selection surrounding the new Annex 1.

Schedule a meet up with one of the Ardmac team. Contact us directly or through Linkedin. We would be delighted to see you at any of the following events

#ArdmacEvents Upcoming events

#ArdmacEvents AT london 2023 Germfree’s Business Development Director George Walker presented at Advanced Therapies London this month. George’s presentation was entitled: Skip the Cleanroom Queue: Offsite Modular Construction. It was well received and the team showcased the mobile cGMP cleanroom 3D printed trailer with virtual reality walkthrough.

#ArdmacEvents ISPE Europe Annual conference

Ardmac’s Managing Director for Cleanrooms and Pre- Construction Enda Murphy and Business Development Director George Walker were at the 2023 ISPE Europe Annual conference in Amsterdam.

Oct 04-05 Cell and Gene Therapy

Oct 10-11 Healthcare Estates Conference & Exhibition George Walker

Nov 30 ISPE UK Annual conference Ardmac Sponsored

World Summit Michael Quinn & George Walker

At Ardmac we want to encourage our people to look after their wellbeing by creating opportuntites to: improve our physical health, focus on our mental health, consider our financial wellbeing, get to know our colleagues better (social), celebrate equality, diversity & inclusion and by

giving back to our communities. Ardmac Annual Cycle for Hope 2023

On Sunday 10th of September, World Suicide Prevention Day, we gathered to Cycle for Hope once again in aid of Pieta House. We were delighted to have such strong engagement from our contacts in the construction industry. Ardmac matched all funding and as a result we have raised over €62,000! We hope to have also encouraged conversation and raised awareness of mental health services and supports through our campaigns in the months leading up to the Cycle for Hope itself.

Pieta provide professional, one-to-one therapeutic services to people who are in suicidal distress, those who engage in self-harm, and those bereaved by suicide https://www.pieta.ie The funds raised will support and provide services to many who are going through their most difficult moments. We hosted the cycle from Swords Business Campus with great support from Swords Cycling Club. Cyclists joined us from all over Ireland and even flew in from overseas to participate. We had 123 fantastic cyclists and walkers on the day.

€62,000 raised, 123 Cyclists

“Cycle for Hope embodies our dedication to ‘building better’ in the community. It’s more than an event; it’s a testament to our own values, uniting our community to make a tangible difference for a fantastic organisation like Pieta, that supports people during their most challenging times. We are committed to giving back where we can, and we take that very seriously. Building our community is key to a better tomorrow for all generations.”

Roy Millar, Chief Business Officer

Ardmac Dublin Swords Business Campus, Swords, Co. Dublin, K67 D8H0, Ireland. E: info@ardmac.com T: +353 (0) 1 894 8800 Ardmac Manchester 4 Scholar Green Road , Cobra Court,Trafford Park, Manchester M32 0TR, England. E: info@ardmac.com T: +44 (0) 161 8668086

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