New materials-based strategies for advanced therapeutics and ultrasensitive biosensing Molly Stevens Imperial College London, UK In this talk I will discuss highlights of our nanomedicine portfolio including nanosensors for diagnosing and monitoring infectious and non-communicable diseases [1], and high molecular weight polymer carriers for enhanced delivery of saRNA therapeutics [2]. I will present advances in Raman spectroscopy for high-throughput label-free characterization of single nanoparticles (SPARTA™) that allow us to integrally analyse a broad range bio-nanomaterials such as polymer particles, liposomes and extracellular vesicles without any modification [3]. SPARTA™ has become an integral tool for the design of nanotherapeutics, with recent examples including DOPC-containing lipid nanoparticles for nucleic acid delivery and dendrimersome-based systems for controlled delivery of antibacterial drugs, and for profiling extracellular vesicles (EVs) for detection of breast cancer through a minimally invasive liquid biopsy. I will also discuss our cell interfacing nanoneedle platforms for multiplexed intracellular biosensing at sub-cellular resolution and modulation of biological processes [4].I will explore how these versatile technologies can be applied to transformative biomedical innovations. References 1. C. S. Wood, … M. M. Stevens. Nature. 2019. 566: 467-474.; C. N. Loynachan, … M. M. Stevens. Nature Nanotechnology. 2019. 14: 883–890.; M. Broto, … M. M. Stevens. Nature Nanotechnology. 2022. DOI: 10.1038/s41565-022-01179-0. 2. A. Blakney, … M. M. Stevens. ACS Nano. 2020, 14(5): 5711-5727. 3. J. Penders, … M. M. Stevens. Nature Communications. 2018, 9: 4256.; J. Penders, … M. M. Stevens. ACS Nano. 2021, 15, 11, 18192–18205; H. Barriga, … M. M. Stevens. Advanced Materials. 2021, 34(26):2200839. 4. C. Chiappini, … M. M. Stevens, E. Tasciotti. Nature Materials. 2015, 14: 532.
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