2026 Express Scripts National Preferred Formulary

Drug Class

Excluded Medications

Preferred Alternatives

testosterone cypionate, testosterone enanthate, XYOSTED

AVEED, AZMIRO

ENDOCRINE (continued) Testosterone Products

KYZATREX, NATESTO, TLANDO, UNDECATREX ADTHYZA 16.25MG, 32.5MG, 65MG, 97.5MG, 130MG LEVOTHYROXINE CAPSULES, THYQUIDITY, TIROSINT, TIROSINT-SOL

testosterone gel, testosterone solution levothyroxine tablets, thyroid pork, ARMOUR THYROID

Thyroid Replacement Therapy

levothyroxine tablets

Miscellaneous Endocrine Agents

CORTROPHIN GEL

No alternatives recommended

GASTROINTESTINAL Antidiarrheal Agents Antiemetics (Injectable)

opium tincture, MYTESI

diphenoxylate/atropine, loperamide

CINVANTI, FOCINVEZ

fosaprepitant injection

granisetron, ondansetron, aprepitant, VARUBI TABLETS

AKYNZEO CAPSULES

ANTIVERT, MECLIZINE 50MG TABLETS

meclizine 25mg tablets granisetron, ondansetron doxylamine/pyridoxine hcl aprepitant, VARUBI TABLETS

ANZEMET BONJESTA

Antiemetics (Oral)

EMEND POWDER PACKETS

ONDANSETRON ODT 16MG TABLETS

ondansetron odt 4mg or 8mg tablets

magnesium sulfate/potassium sulfate/sodium sulfate solution, peg 3350/ascorbic acid powder packets

Bowel Evacuants

CLENPIQ, PLENVU, SUFLAVE, SUTAB

Constipation Agents Corticosteroids (Rectal Formulations)

RELISTOR TABLETS

lubiprostone, MOVANTIK, SYMPROIC

CORTIFOAM

budesonide foam, hydrocortisone enema

Gallstone Dissolution Agents

RELTONE

ursodiol

Gastroparesis Agents

GIMOTI

No alternatives recommended hydrocortisone ac suppositories, pramoxine/hydrocortisone cream pramoxine/hydrocortisone cream

HYDROCORTISONE/PRAMOXINE 25-18MG SUPPOSITORIES

Hemorrhoidal Preparations

PROCTOFOAM-HC

balsalazide disodium, mesalamine dr, mesalamine er, sulfasalazine, PENTASA 250MG CAPSULES

Inflammatory Bowel Agents

DIPENTUM

Irritable Bowel Syndrome & Chronic Constipation Agents

IBSRELA

lubiprostone, prucalopride, LINZESS, TRULANCE

Pancreatic Enzymes

PERTZYE

CREON, PANCREAZE, ZENPEP

esomeprazole magnesium capsules, lansoprazole capsules, omeprazole capsules, pantoprazole tablets, rabeprazole tablets esomeprazole magnesium, lansoprazole, omeprazole, pantoprazole, rabeprazole

dexlansoprazole, DEXILANT

Proton Pump Inhibitors

KONVOMEP, PRILOSEC SUSPENSION, RABEPRAZOLE DR SPRINKLE

Miscellaneous Gastrointestinal Agents

DARTISLA ODT

glycopyrrolate tablets

HEMATOLOGICAL Antiplatelet Agents

aspirin plus omeprazole, esomeprazole magnesium, lansoprazole, pantoprazole or rabeprazole

YOSPRALA DR

(continued)

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CRP1386903A 204612 EXCL-NPF-26 (08/08/2025)

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