2026 Express Scripts National Preferred Formulary

Drug Class

Excluded Medications

Preferred Alternatives

COMBOGESIC

ibuprofen plus acetaminophen

COXANTO, DICLOFENAC 35MG CAPSULES, DOLOBID, FENOPROFEN 200MG CAPSULES, FENOPRON, KETOROLAC NASAL SPRAY, OXAPROZIN 300MG CAPSULES, RELAFEN DS, SPRIX, ZORVOLEX

MUSCULOSKELETAL & RHEUMATOLOGY (continued) Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

generic oral nonsteroidal anti-inflammatory drugs

ELYXYB

celecoxib

MELOXICAM SUSPENSION

ibuprofen suspension, naproxen suspension

Topical Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

DICLOFENAC EPOLAMINE PATCHES

FLECTOR, LICART

OBSTETRICAL & GYNECOLOGICAL Combination Patches

CLIMARA PRO

COMBIPATCH

FEMLYV, LO LOESTRIN FE, NATAZIA, NEXTSTELLIS, TWIRLA, TYBLUME

generic oral, patch and ring contraceptives

Contraceptives

Barrier methods of contraception, such as condoms, diaphragms or spermicides.

PHEXXI

SLYND

generic progestin-only oral contraceptives estradiol cream, estradiol vaginal inserts, PREMARIN CREAM

ESTRING, IMVEXXY, INTRAROSA, OSPHENA

Estrogen & Estrogen Modifiers for Vaginal Symptoms

estradiol cream, estradiol patches, estradiol tablets, estradiol vaginal inserts, PREMARIN CREAM

FEMRING

Estrogen/Progestin Combinations (Oral)

estradiol/norethindrone acetate, ethinyl estradiol/norethindrone acetate

BIJUVA, PREMPHASE, PREMPRO

Estrogens (Oral)

MENEST, PREMARIN TABLETS

estradiol tablets

CHORIONIC GONADOTROPIN 10,000 UNITS, NOVAREL

Human Chorionic Gonadotropin

OVIDREL, PREGNYL

GONAL-F, GONAL-F RFF, GONAL-F RFF REDI-JECT generic prenatal vitamins

Ovulatory Stimulants (Follitropins)

FOLLISTIM AQ

Prenatal Vitamins

CITRANATAL, NATAL PNV, PREGENNA, TRINAZ

Topical Estrogen Agents

ELESTRIN

estradiol gel, gel pump or patches

medroxyprogesterone, megestrol, norethindrone, progesterone paroxetine hcl, paroxetine hcl ext-release Coverage may be approved for the treatment of Acute Myeloid Leukemia under certain conditions.

Vaginal Progesterones

CRINONE 4%

Miscellaneous Gynecological Agents paroxetine mesylate

ONUREG

ONCOLOGY Acute Myeloid Leukemia (AML) Agents

REZLIDHIA VANFLYTA GRAFAPEX

TIBSOVO RYDAPT

Alkylating Agents

busulfan, cyclophosphamide, etoposide, fludarabine Coverage may be approved for the treatment of Diffuse Large B-cell Lymphoma under certain conditions.

B-Cell Lymphoma Agents

COLUMVI

(continued)

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CRP1386903A 204612 EXCL-NPF-26 (08/08/2025)

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