2026 Express Scripts National Preferred Formulary

Drug Class

Excluded Medications

Preferred Alternatives

Coverage may be approved for the treatment of Diffuse Large B-cell Lymphoma under certain conditions. For Follicular Lymphoma: LUNSUMIO

ONCOLOGY B-Cell Lymphoma Agents (continued)

EPKINLY

Bendamustine Agents

VIVIMUSTA

bendamustine, BENDEKA

Bevacizumab-Containing Agents Bispecific Human Epidermal Growth Factor Receptor 2 (HER2)-Directed Antibody

ALYMSYS, AVASTIN, VEGZELMA

ZIRABEV

ZIIHERA

PERJETA plus HERCESSI or OGIVRI

Bortezomib Agents

BORUZU

bortezomib

For Mantle Cell Lymphoma: BRUKINSA, CALQUENCE For Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma: BRUKINSA, CALQUENCE, IMBRUVICA, VENCLEXTA

Bruton Tyrosine Kinase Inhibitors JAYPIRCA

Docetaxel Agents

DOCIVYX BESREMI

docetaxel

Interferons

hydroxyurea

Coverage may be approved for the treatment of Breast Cancer under certain conditions.

Kinase Inhibitors

ITOVEBI

Melphalan Agents (Injectable)

IVRA

melphalan injection

bortezomib, DARZALEX, KYPROLIS, POMALYST, REVLIMID, THALOMID

Multiple Myeloma Agents

XPOVIO

Myelodysplastic Syndrome Agents

INQOVI

decitabine

Myelofibrosis Agents

INREBIC, OJJAARA

JAKAFI

Coverage may be approved for the treatment of KRAS G12C-mutated non-small cell lung cancer.

KRAZATI

Non-Small Cell Lung Cancer Agents

TEPMETKO

TABRECTA LYNPARZA

PARP Inhibitors

RUBRACA, ZEJULA

Pemetrexed Agents

AXTLE

pemetrexed disodium

abiraterone plus LYNPARZA, TALZENNA plus XTANDI

AKEEGA

Prostate Cancer Agents

ELIGARD, FIRMAGON, LUPRON DEPOT, LUTRATE DEPOT

CAMCEVI, LEUPROLIDE DEPOT, TRELSTAR

Renal Cell Cancer Agents Rituximab-Containing Agents Thiotepa Injectable Agents

FOTIVDA

CABOMETYX, INLYTA, LENVIMA

RIABNI, RITUXAN, RITUXAN HYCELA, TRUXIMA RUXIENCE

TEPYLUTE

thiotepa

HERCEPTIN, HERCEPTIN HYLECTA, HERZUMA, KANJINTI, ONTRUZANT, TRAZIMERA

Trastuzumab-Containing Agents

HERCESSI, OGIVRI

dasatinib, imatinib, nilotinib, pazopanib, sorafenib, sunitinib, IMKELDI, STIVARGA timolol drops, betaxolol drops, carteolol drops, levobunolol drops

Tyrosine Kinase Inhibitors

QINLOCK

OPHTHALMIC Antiglaucoma Agents (Beta-Adrenergic Blockers)

BETIMOL, TIMOPTIC OCUDOSE

(continued)

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CRP1386903A 204612 EXCL-NPF-26 (08/08/2025)

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