2026 Express Scripts National Preferred Formulary

Drug Class

Excluded Medications

Preferred Alternatives

OPHTHALMIC (continued) Antiglaucoma Agents (Ophthalmic Prostaglandins)

tafluprost drops, travoprost drops, DURYSTA, IDOSE TR, IYUZEH, LUMIGAN, TRAVATAN Z, VYZULTA, XELPROS, ZIOPTAN

bimatoprost drops, latanoprost drops

Blepharoptosis Agents

UPNEEQ

No alternatives recommended

Ophthalmic Agents (Complement Protein C5 Inhibitors)

Coverage may be approved for the treatment of Geographic Atrophy under certain conditions.

IZERVAY

EYLEA, EYLEA HD, VABYSMO

PAVBLU

Ophthalmic Agents (Vascular Endothelial Growth Inhibitors)

LUCENTIS SUSVIMO

BYOOVIZ, CIMERLI

No alternatives recommended

ATROPINE (PRESERVATIVE FREE) 1% EYE SINGLE USE DROPPERETTE

atropine 1% drops

CYSTADROPS QLOSI, VUITY

CYSTARAN

Ophthalmic Agents (Other)

No alternatives recommended

azelastine drops, bepotastine drops, cromolyn drops, epinsatine drops, olopatadine drops azelastine drops, bepotastine drops, cromolyn drops, epinastine drops, olopatadine drops dexamethasone drops, difluprednate drops, fluorometholone drops, loteprednol 0.5% drops, prednisolone drops

VERKAZIA

Ophthalmic Anti-Allergic

ALOMIDE, ALREX, ZERVIATE

CLOBETASOL DROPS, FLAREX, FML FORTE, MAXIDEX, PRED MILD

Ophthalmic Anti-Inflammatory

Ophthalmic Combinations

TOBRADEX ST, ZYLET

tobramycin/dexamethasone drops

Ophthalmic Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

ACUVAIL, NEVANAC

bromfenac drops, diclofenac drops, ketorolac drops

ciprofloxacin drops, gatifloxacin drops, levofloxacin drops, moxifloxacin drops, ofloxacin drops

Ophthalmic Quinolone Antibiotics BESIVANCE, CILOXAN OINTMENT

DUROLANE, EUFLEXXA, GEL-ONE, GELSYN-3, GENVISC 850, HYALGAN, HYMOVIS, SUPARTZ FX, SYNOJOYNT, SYNVISC, SYNVISC-ONE, TRILURON, TRIVISC, VISCO-3

OSTEOARTHRITIS Hyaluronic Acid Derivatives

MONOVISC, ORTHOVISC

RENAL Nephropathic Cystinosis Agents

PROCYSBI

CYSTAGON

OXYBUTYNIN 2.5MG

oxybutynin solution or syrup, oxybutynin 5mg tablets

Overactive Bladder Agents

oxybutynin solution or syrup, MYRBETRIQ ER SUSPENSION

VESICARE LS

FERRIC CITRATE, FOSRENOL POWDER PACKETS, VELPHORO, XPHOZAH URIMAR-T CAPSULES, URNEVA

calcium acetate, lanthanum, sevelamer carbonate, sevelamer hcl

Phosphate Binders

Miscellaneous Urologicals

uro mp, uro sp

carbinoxamine liquid and 4mg tablets; cetirizine solution and syrup; desloratidine tablets; hydroxyzine solution, syrup and tablets; levocetirizine solution and tablets epinephrine auto-injector (by Mylan, Teva), AUVI-Q, EPIPEN, EPIPEN JR

RESPIRATORY Antihistamines (Oral)

clemastine, CARBINOXAMINE ER 4MG/5ML SUSPENSION, KARBINAL ER SUSPENSION

EPINEPHRINE AUTO-INJECTOR (by Amneal Pharma, Avkare)

Epinephrine Auto-Injector Systems

(continued)

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CRP1386903A 204612 EXCL-NPF-26 (08/08/2025)

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