2026 Express Scripts National Preferred Formulary

Drug Class

Excluded Medications

Preferred Alternatives

MISCELLANEOUS AGENTS (continued) Gaucher Disease Agents

ELELYSO, VPRIV

CEREZYME

ALKINDI SPRINKLE

hydrocortisone tablets dexamethasone tablets CINRYZE, RUCONEST

Glucocorticoids

HEMADY BERINERT

Hereditary Angioedema

SC: GAMMAGARD LIQUID, GAMUNEX-C, XEMBIFY IV: GAMMAGARD LIQUID, GAMMAGARD S-D, GAMUNEX-C SC: GAMMAGARD LIQUID, GAMUNEX-C, XEMBIFY

CUTAQUIG, HYQVIA

Immune Globulins

GAMMAKED

ENVARSUS XR

tacrolimus capsules methotrexate tablets IMBRUVICA, JAKAFI methotrexate injection

JYLAMVO, TREXALL, XATMEP

Immunosuppressant Agents

NIKTIMVO

OTREXUP, RASUVO

Inflammatory Conditions Agents Infused Non-TNF Biologics - Tocilizumab Intravenous Agents Infused Non-TNF Biologics - Ustekinumab Agents

SOVUNA

hydroxychloroquine tablets

ACTEMRA IV, TOFIDENCE IV

TYENNE IV

SELARSDI IV, USTEKINUMAB-TTWE IV (by Quallent), YESINTEK IV, ENTYVIO IV, OMVOH, SKYRIZI, TREMFYA

OTULFI IV, PYZCHIVA IV, STELARA IV, STEQEYMA IV, USTEKINUMAB IV, WEZLANA IV

Infused TNF Antagonists

INFLECTRA, REMICADE, RENFLEXIS

AVSOLA, INFLIXIMAB

RAVICTI

sodium phenylbutyrate, PHEBURANE

Coverage may be approved for the treatment of Primary Hyperoxaluria Type 1 under certain conditions. Coverage may be approved for the treatment of generalized myasthenia gravis.

Metabolic Agents

RIVFLOZA

IMAAVY, RYSTIGGO

Myasthenia Gravis Agents

ZILBRYSQ

SOLIRIS

Neuromyelitis Optica Spectrum Disorder Agents

UPLIZNA

ENSPRYNG

ibuprofen/famotidine

ibuprofen tablets plus famotidine tablets naproxen tablets, naproxen sodium tablets or naproxen ec tablets plus esomeprazole magnesium capsules alendronate, ibandronate, risedronate, teriparatide, zoledronic acid, TYMLOS

NSAID & Acid Reducing Agent Combination Products

naproxen/esomeprazole magnesium, VIMOVO

Osteoporosis (Bone Modifiers)

EVENITY, PROLIA

Polyneuropathy of Hereditary Transthyretin-Mediated Amyloidosis Potassium Replacement Agents

ONPATTRO, WAINUA

AMVUTTRA

POKONZA

potassium chloride

Weight Loss

SAXENDA, ZEPBOUND VIALS

WEGOVY, ZEPBOUND PENS

Wilson’s Disease Agents

CUVRIOR, TRIENTINE 500MG CAPSULES

trientine 250mg capsules

(continued)

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CRP1386903A 204612 EXCL-NPF-26 (08/08/2025)

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