2026 Express Scripts National Preferred Formulary

Indication Based Management

Drug Class

Excluded Medications

Preferred Alternatives

ADALIMUMAB-AACF, IDACIO ADALIMUMAB-AATY, YUFLYMA ADALIMUMAB-FKJP, HULIO

ABRILADA AMJEVITA CYLTEZO HADLIMA HUMIRA HYRIMOZ YUSIMRY

ADALIMUMAB-ADAZ ADALIMUMAB-ADBM (by Boehringer Ingelheim & Quallent) ADALIMUMAB-RYVK (by Quallent), SIMLANDI

Adalimumab Products for Inflammatory Conditions ‡

Tocilizumab Products for Inflammatory Conditions ‡ Ustekinumab Products for Inflammatory Conditions ‡

ACTEMRA SC

TYENNE SC

OTULFI SC, PYZCHIVA SC, STELARA SC # , STEQEYMA SC, USTEKINUMAB SC, USTEKINUMAB-AEKN SC, WEZLANA SC

SELARSDI SC, USTEKINUMAB-TTWE SC (by Quallent), YESINTEK SC

Referenced excluded medications for Inflammatory Conditions ‡ as indicated

KINERET, SILIQ

See below for Preferred Alternatives

Drug Class

Other Medications

Preferred Alternatives

Preferred: ADALIMUMAB-ADAZ, ADALIMUMAB-ADBM (by Boehringer Ingelheim & Quallent), ADALIMUMAB-RYVK (by Quallent), ENBREL, OMVOH SC, OTEZLA, RINVOQ, RINVOQ LQ, SELARSDI SC, SIMLANDI, SKYRIZI, SOTYKTU, TALTZ, TREMFYA SC, USTEKINUMAB-TTWE SC (by Quallent), VELSIPITY, XELJANZ, XELJANZ SOLUTION, XELJANZ XR, YESINTEK SC, ZYMFENTRA Preferred for Non-Radiographic Axial Spondyloarthritis (nr-axSpA) only: CIMZIA, TALTZ Preferred after use of one Preferred Medication: CIMZIA (for Crohn’s Disease only), SIMPONI 100MG, TYENNE SC

All other Brand Name medications for Inflammatory Conditions may require a trial of one or more Preferred medications as part of the Formulary exceptions process.

Inflammatory Conditions ‡

‡ Please note that formulary and product placement for treatment of Inflammatory and Atopic Conditions in the Inflammatory and Atopic Conditions Care Value (IACCV) Program are subject to change throughout the year based upon changes in market dynamics, new indications for existing products, biosimilar and new product launches. # Continuation of Therapy applies through June 30, 2026; Excluded for all utilizers effective July 1, 2026.

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CRP1386903A 204612 EXCL-NPF-26 (08/08/2025)

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