2026 Express Scripts National Preferred Formulary

Drug Class

Excluded Medications

Preferred Alternatives

VYEPTI

AIMOVIG, AJOVY, EMGALITY

AUTONOMIC & CENTRAL NERVOUS SYSTEM Antimigraine Agents (continued)

eletriptan, naratriptan, rizatriptan, sumatriptan, NURTEC ODT, UBRELVY Coverage may be approved for the treatment of Parkinson’s Disease under certain conditions.

ZAVZPRET

APOKYN

DHIVY

carbidopa/levodopa

GOCOVRI ER

amantadine

Antiparkinsonism Agents

cabergoline, entacapone, pramipexole, rasagiline, ropinirole

NOURIANZ

ONAPGO, VYALEV XADAGO, ZELAPAR

carbidopa/levodopa er rasagiline, selegiline

risperidone er, ABILIFY ASIMTUFII, ABILIFY MAINTENA, ARISTADA, ARISTADA INITIO, ERZOFRI, RYKINDO ER, UZEDY ER aripiprazole, asenapine, lurasidone, olanzapine, paliperidone er, quetiapine tablets (except 150mg), risperidone, ziprasidone

INVEGA HAFYERA, INVEGA SUSTENNA, INVEGA TRINZA

Antipsychotics (Injectable)

COBENFY, FANAPT

Antipsychotics (Oral)

OPIPZA

aripiprazole odt or oral solution quetiapine 50mg or 100mg tablets baclofen solution, suspension or tablets metaxalone 400mg or 800mg tablets

QUETIAPINE 150MG TABLETS LYVISPAH, OZOBAX, OZOBAX DS METAXALONE 640MG TABLETS

Antispasmodic Agents

BUCAPSOL LOREEV XR

buspirone

Anxiolytic Agents

lorazepam tablets

LUMRYZ ER, SODIUM OXYBATE (by Hikma), XYWAV dextroamphetamine er, dextroamphetamine/ amphetamine er, lisdexamfetamine dexmethylphenidate er, methylphenidate cd, methylphenidate er, methylphenidate la, AZSTARYS

Cataplexy Treatment

SODIUM OXYBATE (by Amneal), XYREM

DYANAVEL XR, XELSTRYM

Central Nervous System Stimulants

METHYLPHENIDATE ER 45MG, 63MG & 72MG, QUILLICHEW ER, QUILLIVANT XR, RELEXXII ER

ONYDA XR

clonidine er tablets

prednisolone solution/syrup, prednisolone tablets, prednisone solution, prednisone tablets

AGAMREE

AMONDYS 45, EXONDYS 51, VILTEPSO, VYONDYS 53

Duchenne Muscular Dystrophy (DMD) Agents

No alternatives recommended

Coverage may be approved for the treatment of Duchenne Muscular Dystrophy under certain conditions.

DUVYZAT

Movement Disorders Therapy

AUSTEDO, AUSTEDO XR

INGREZZA, INGREZZA SPRINKLE

BRIUMVI

KESIMPTA, OCREVUS, OCREVUS ZUNOVO dimethyl fumarate, fingolimod, teriflunomide, BAFIERTAM, MAYZENT, VUMERITY, ZEPOSIA (for Multiple Sclerosis only)

Multiple Sclerosis Agents

GILENYA, PONVORY, TASCENSO ODT

(continued)

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CRP1386903A 204612 EXCL-NPF-26 (08/08/2025)

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