2026 Express Scripts National Preferred Formulary

Drug Class

Excluded Medications

Preferred Alternatives

CONZIP, QDOLO, TRAMADOL 25MG & 75MG TABLETS, TRAMADOL ER CAPSULES, TRAMADOL SOLUTION

tramadol 50mg & 100mg tablets, tramadol er tablets

hydromorphone tablets, morphine tablets, oxycodone tablets, oxymorphone tablets hydrocodone/acetaminophen, morphine sulfate, oxycodone, tramadol, tramadol/acetaminophen hydrocodone bitartrate er, hydromorphone er, morphine sulfate er, oxymorphone hcl er, HYSINGLA ER

levorphanol

AUTONOMIC & CENTRAL NERVOUS SYSTEM (continued) Narcotic Analgesics & Combinations

NUCYNTA

NUCYNTA ER, OXYCODONE ER, OXYCONTIN, XTAMPZA ER OXAYDO, OXYCODONE COATED TABLETS, ROXYBOND

oxycodone uncoated tablets

PRIMLEV, PROLATE SOLUTION

oxycodone/acetaminophen

SEGLENTIS

tramadol 50mg tablets plus celecoxib

Narcotic Antagonists Niemann-Pick Disease Type C Agents Rett Syndrome Agents

ZIMHI

naloxone syringes

MIPLYFFA

AQNEURSA

DAYBUE

No alternatives recommended

DORAL, QUAZEPAM

estazolam, lorazepam

Sedative-Hypnotic Agents

ZOLPIDEM 7.5MG CAPSULES

eszopiclone, zaleplon, zolpidem tablets citalopram tablets, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, vilazodone desvenlafaxine er, duloxetine, venlafaxine hcl er, FETZIMA

Selective Serotonin Reuptake Inhibitors (SSRIs) Antidepressants Serotonin/Norepinephrine Reuptake Inhibitor Antidepressants

CITALOPRAM CAPSULES

DRIZALMA SPRINKLE, VENLAFAXINE BESYLATE ER

FENTANYL CITRATE BUCCAL TABLETS, FENTORA

Transmucosal Fentanyl Analgesics

fentanyl citrate lozenges

APLENZIN, BUPROPION XL 450MG, FORFIVO XL bupropion xl 150mg or 300mg RALDESY trazodone tablets

Miscellaneous Antidepressants

olanzapine/fluoxetine, bupropion, desvenlafaxine er, duloxetine, escitalopram, mirtazapine, sertraline tablets

SPRAVATO

CARDIOVASCULAR ACE Inhibitors

QBRELIS

lisinopril

Alpha-Adrenergic Agonists

CLONIDINE ER 0.17MG, NEXICLON XR

clonidine patches, clonidine tablets

candesartan, irbesartan, losartan, olmesartan, telmisartan, valsartan

EDARBI

candesartan/hydrochlorothiazide, irbesartan/hydrochlorothiazide, losartan/hydrochlorothiazide, olmesartan/hydrochlorothiazide, telmisartan/hydrochlorothiazide, valsartan/hydrochlorothiazide, chlorthalidone plus valsartan

Angiotensin Receptor Blockers (ARBs) & Combinations

EDARBYCLOR

(continued)

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CRP1386903A 204612 EXCL-NPF-26 (08/08/2025)

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