Beyond Hyaluronic Acid (HA) and Collagen Stimulators
Ellansé versus Collagen Stimulators
HIGH QUALITY SCAFFOLD
SMOOTH
SPHERICAL MICROPARTICLES
IMMEDIATE AND SUSTAINED PERFORMANCE • Collagen stimulation induces long-term volumising capacity, for lasting, natural-looking results from a minimum of 18 months to 24 months.* • Immediate results compared to Poly-L-Lactic Acid (PLLA)-based filler. • Improved stability and duration compared to Calcium Hydroxylapatite (CaHA)-based filler.
Ellansé versus Hyaluronic Acid Fillers
Light microscopy: Histology 2-weeks post-injection
Light microscopy picture
Scanning Electron Microscope picture (SEM)
COLLAGEN STIMULATOR
POLYMER/ MINERAL ◊
Ellansé offers clear advantages over the NASHA-based dermal filler in terms of performance, durability and efficacy. A split-face clinical study by Galadari et al. (2015) evaluated the safety and efficacy of Ellansé S with the HA dermal filler, Perlane, when used to treat moderate to severe nasolabial folds (n=40). Efficacy was compared using the mean wrinkle severity rating score (WSRS).
• Statistically superior to an HA dermal filler, Ellansé outperforms non-animal stabilised hyaluronic acid (NASHA)- based dermal filler in both effectiveness and longevity. 10 • Compared to the NASHA-based dermal filler effect, results show that Ellansé achieved the optimal result with a 17% lower injection volume. 10 • Ellansé was shown to build greater structural support and volumisation, with significantly higher elasticity (G’ of 1,000 Pa) than the NASHA dermal filler. 7 • After neocollagenesis, Ellansé provides an elastic modulus almost equal to that of the dermis and is cosmetically more favourable than an HA dermal filler. 7
SIZE
SHAPE
SURFACE DURATION
Ellansé
PCL
25 - 50 µm Spherical
Smooth
From 18-24 months* 16
Generally spherical
CaHA
25 - 45 µm
Smooth
Over 12 months 17
Radiesse ®
◊
Sculptra ®
PLLA
40 - 63 µm Irregular
Irregular
25 months** 18
SMOOTHER, MORE SPHERICAL MICROSPHERES. 11-15 Ellansé is composed of smooth, spherical
PCL particles with a diameter of 25-50μm. Since rough surfaces and irregular-shaped particles can cause adverse reactions (such as nodules and decreased collagen deposition), it’s been specifically designed for optimum compatibility with the body.
Ellansé microspheres Circularity (mean) † 0.997
Circularity (mean) † 0.994 Radiesse microspheres
Circularity (mean) † 0.682 Sculptra microspheres
Comparative clinical study of Ellansé versus NASHA for treatment of nasolabial folds 10
SUMMARY
PCL
NASHA
Mean Wrinkle Severity Rating Score (WSRS)
4.00
3.53
3.50
A
B
C
Baseline
3.55
3.05
3.00
2.87
PCL
2.54
2.50
NASHA
Smooth surface compared to PLLA-based filler.
Improved, long-term volume and control of mass loss compared to CaHA-based filler.
Longer-lasting results compared to PLLA and CaHA-based fillers with no top-up sessions required.
2.29
2.57**
2.57
2.21
2.16**
2.00
2.00*
12 months
1.88
1.50
Baseline Month 1 Month 3 Month 6 Month 9 Month 12
*P < 0.05 **P < 0.005
* Treatment effects have variable duration dependant on the variant used, practitioner injection technique, patient lifestyle and metabolic rate. ** Expected duration of action based on three sessions. † Roundness calculated by Flow Particle Image Analyser (FPIA).
10 ELLANSÉ PRACTITIONER GUIDE
11 ELLANSÉ PRACTITIONER GUIDE
Made with FlippingBook interactive PDF creator