Stewardship Report Volume 8 - Winter 2025

Research and Science / Research — Rare Subtypes

Spotlighting a Mucosal Melanoma Career Development Award Neoadjuvant immunotherapy and radiotherapy for mucosal melanoma “Our project aims to improve outcomes for patients with mucosal melanoma, a rare subtype of melanoma arising from non-skin surfaces like the inside of the nose and sinuses or the anogenital tract. Despite major advances in melanoma treatments broadly, patients with this diagnosis continue to have significantly worse prognosis than those with more common cutaneous melanomas. Specifically, wwe are investigating if adding preoperative radiotherapy to immunotherapy is a novel treatment strategy that can improve disease control and quality of life while also looking for biomarkers that predict for response to therapy and outcomes.”

Spotlighting a Uveal Melanoma Career Development Award Assessment of Uveal Melanoma Using Machine Learning “The goal of our research is to improve the detection and diagnosis of eye tumors. By helping doctors diagnose uveal melanoma earlier, we aim to ensure that patients receive timely treatment and the best overall care for those affected.”

Devarati Mitra, MD, PhD MD Anderson Cancer Center

Michael Heiferman, MD University of Illinois at Chicago

Publications The 2023 Cure Ocular Melanoma (CURE OM) Global Science meeting in Philadelphia focused on advancing research, treatment and patient advocacy for ocular melanoma (OM). The report, published on October 9, 2024, in Pigment Cell and Melanoma

Spotlighting a Pediatric Melanoma Resident Fellow Award Predictors of Nodal Metastases in Pediatric Melanomas

Kevin Nguyen West Virginia University Research Corporation

“Pediatric melanoma is a rare entity, and our study aims to discover factors that shape how this disease behaves aggressively to better guide patient-centered treatment decisions.”

Research , covers genetics, therapies and clinical trials to improve outcomes. The meeting aimed to enhance collaboration among researchers, clinicians and patients to improve outcomes for those affected by this rare cancer. Key presentations highlighted the latest findings in genetics, therapies and clinical trials, fostering a omprehensive dialogue on future directions in OM research.

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