S2557
Radiobiology - Microenvironment
ESTRO 2026
during hypoxia and improve patient outcomes. References: 1 The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy. Hypoxia (Auckl)3, 83-92, doi:10.2147/HP.S93413 (2015).2 Child, F. et al. The hypoxic ECM and Muz, B., de la Puente, P., Azab, F. & Azab, A. K. neutrophils in MIBC immunotherapy resistance. Nature Reviews Urology, doi:10.1038/s41585-025- 01092-w (2025).3 Smith, V. et al. Hypoxia Is Associated with Increased Immune Infiltrates and Both Anti-Tumour and Immune Suppressive Signalling in Muscle-Invasive Bladder Cancer. International Journal of Molecular Sciences24, 8956 (2023).4 Shinde- Jadhav, S. et al. Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer. Nature communications12, 2776 (2021). Keywords: Immunotherapy, myeloid cells
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