S2566
Radiobiology – Normal tissue radiobiology
ESTRO 2026
Conclusion: The Mongolian gerbil is appropriate for developing anRP model. Furthermore, 5-MIAA and Lactobacillus reuteri are promising radioprotective agents. References: 1. Moraitis, I., J. Guiu, and J. Rubert, Gut microbiota controlling radiation-induced enteritis and intestinal regeneration. Trends Endocrinol Metab, 2023. 34(8): p. 489-501.2. Li Wei, et al., Study on the intestinal morphology and energy demands in Mongolian gerbil. CHINESE JOURNAL OF COMPARATIVE MEDICINE, 2016. 26(1): p. 37-41.3. Lee, M.J., D.J. Lee, and H.S. Jung, Wound healing mechanism in Mongolian gerbil skin. Histochem Cell Biol, 2019. 151(3): p. 229-238.4. Ma, C., et al., Outcomes of Radiotherapy for Osseous Echinococcosis of Meriones meridianus. Biomed Res Int, 2020. 2020: p. 6457419. Keywords: Radiation proctitis, Mongolian gerbils Digital Poster Highlight 1884 Periplaneta americana extract attenuates radiation-induced enteritis by modulating the gut microbiota Shun Lu, Wei Tang, Jie Zhou Precision Radiation in Oncology Key Laboratory of Sichuan Province, Sichuan Cancer Hospital & Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China Purpose/Objective: Aimed to systematically evaluate the role of Periplaneta americana extract (PAE) on radiation- induced intestinal injury and elucidate the underlying molecular mechanism. Material/Methods: A murine model of radiation-induced enteritis was established by localized abdominal X-ray irradiation, and PAE was administered by oral gavage at a dose of 100 mg/kg before and after irradiation. Body weight, diarrhea score and survival were dynamically monitored as clinical parameters. Hematoxylin–eosin (H&E) staining was used to assess intestinal structural damage, and villus height, crypt depth and goblet cell numbers were quantified. Epithelial apoptosis and proliferation were evaluated by TUNEL staining. Intestinal mucosal barrier function was assessed by measuring the expression of tight junction proteins and performing intestinal permeability assays. The inflammatory response was characterized by determining the levels of TNF- α , IL-1 β , IL-6 and other cytokines in intestinal tissues and serum. Fecal samples were collected for 16S rRNA high-throughput sequencing to analyze the composition, diversity and predicted functions of the gut microbiota. Feces from
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