S2664
RTT - Patient experience and quality of life
ESTRO 2026
covered four domains: informational needs, physical discomfort, psychological coping, and situational coping. Responses were scored on a 4-point Likert scale, with higher scores indicating more favorable experience. The additional time required for the adaptive workflow was measured as the interval between the initial and verification CBCT. Between- group comparisons of mean domain and item scores were conducted using t-tests. Questionnaires were completed by 38 oART and 28 IGRT patients at the beginning, and by 31 and 26 patients, respectively, at the end of therapy. Results: The adaptive workflow increased session time by mean 16.04 (±4.99) minutes. With mean domain scores ranging from 2.04 (±0.8) to 2.71 (±0.4) on a 3- point scale, overall patient-reported experience and satisfaction were high. Physical discomfort consistently received the highest ratings in both groups at both timepoints, while informational needs scored lowest (Table 1). No statistically significant differences in domain or item scores were observed between oART and IGRT at either the first or last treatment week. Within-group item analyses showed stable ratings over time in both cohorts. Minor, non- significant trends suggested slightly greater comfort in treatment position (p = 0.06) and better tolerance of couch time with IGRT at the beginning of therapy (p = 0.074).
anxiety in prostate cancer patients prior to radiotherapy. Integrating prehabilitation, alongside validated psychological assessment tools, into routine practice may enhance patient experience and outcomes. Larger, randomised studies in more diverse populations are warranted to confirm these findings. References: Cancer Research UK (2018). Retrieved August 6, 2024, from https://www.cancerresearchuk.org/health- professional/cancer-statistics/statistics-by-cancer- type/prostate-cancerScriney, A., Russell, A., Loughney, L., Gallagher, P., & Boran, L. (2022). The impact of prehabilitation interventions on affective and functional outcomes for young to midlife adult cancer patients: A systematic review. Psycho-oncology, 31(12),
2050–2062. https://doi.org/10.1002/pon.6029 Keywords: Prostate cancer, Prehabilitation, Radiotherapy
Mini-Oral 2334
Patient-reported experience in online adaptive CBCT-based radiotherapy vs conventional IGRT for prostate cancer: results of a prospective cohort study Jakob Dannehl 1 , Luise Anna Künzel 1 , Kerstin Rubarth 1,2 , Anne Kluge 3 , Thao Thanh Nguyen 1,2 , Celina Höhne 1 , Marcus Beck 1 , Julia Bauer 1 , Daniel Zips 1 , Carolin Senger 1 , Goda Kalinauskaite 1,4 1 Radiation Oncology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and HumboldtUniversität zu Berlin, Berlin, Germany. 2 Institute of Biometry and Clinical Epidemiology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and HumboldtUniversität zu Berlin, Berlin, Germany. 3 Radiation Oncology, University of Leipzig Medical Center, Leipzig, Germany. 4 Berlin Institute of Health, Charité – Universitätsmedizin Berlin, Berlin, Germany Purpose/Objective: To prospectively compare patient-reported experience during daily cone-beam CT (CBCT)-based online adaptive radiotherapy (oART) and conventional CBCT- based image-guided radiotherapy (IGRT) in patients with localized prostate cancer. Material/Methods: Seventy-four patients with localized prostate cancer were enrolled in this single-institution prospective study (NCT06116019). All were scheduled for moderately hypofractionated radiotherapy (62 Gy in 20 fractions) and were assigned to either the oART group (n = 43) or the IGRT group (n = 31). A validated MR-Linac patient-experience questionnaire, adapted for CBCT-based workflows, was administered during begin and end of the treatment (1). The 18 items
Conclusion: Daily CBCT-based oART was well tolerated and provided patient experience comparable to conventional IGRT, despite longer treatment sessions. These findings support a high patient acceptance of CBCT-based online adaptative radiotherapy in patients with prostate cancer. References: 1. Barnes H, Alexander S, Bower L, Ehlers J, Gani C, Herbert T, et al. Development and results of a patient- reported treatment experience questionnaire on a 1.5 T MR-linac. Clin Transl Radiat Oncol. 2021 Sept;30:31– 7. Keywords: adaptive radiotherapy, prostate cancer, PREMs
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