S2669
RTT - Patient experience and quality of life
ESTRO 2026
This sub-study of the HYPO-RT-PC trial enrolled 1180 men from 2005 to 2015. Participants were randomly assigned to receive either conventional fractionated radiotherapy (CF) (2.0 Gy x 39 fx) or ultra-hypo- fractionated radiotherapy (UHF) (6.1 Gy x 7 fx). Urinary and bowel symptoms, as well as sexual function were assessed with the Prostate Cancer Symptom Scale while physicians evaluated symptoms using the Radiation Therapy Oncology Group (RTOG) criteria. Agreement and over- and under-reporting of symptoms are described at baseline, at the end of radiotherapy, and at 1, 2, and 4 years of follow-up. Generalised estimated equations for repeated measures were used to assess whether agreement differed by treatment type. Results: Between 580 and 910 paired assessments were analysed at each timepoint. Agreement between patient and physician ratings varied, with Spearman's correlation coefficient ranging from -0.091 to 0.750. For urinary symptoms, fewer than 50% of assessments showed perfect agreement. Physicians consistently underrated urinary and bowel symptoms across all timepoints, while sexual function was overrated at the first two timepoints. A significant difference in agreement was observed between the two treatment groups for bowel symptoms at the end of radiotherapy and at the one-year follow-up. Conclusion: The agreement between patient-reported symptoms and physicians’ assessments was consistently insufficient across all domains and timepoints. These findings highlight the importance of incorporating and accurately interpreting patient-reported outcome measures in both clinical practice and research to gain a more comprehensive understanding of treatment- related toxicity and the patients quality of life. Keywords: agreement, symptom assessment, PROM, Assessment of Information Accuracy from Large Language Models in Prostate Cancer Education Aoife Kirwan 1,2 , Elizabeth Forde 1,2 1 Applied Radiation Therapy Trinity, Discipline of Radiation Therapy, Trinity College Dublin, Dublin, Ireland. 2 Trinity St James’s Cancer Institute, Trinity College Dublin, Dublin, Ireland Purpose/Objective: Large language models (LLMs) are a form of artificial intelligence tools with potential to support patient education; however, concerns regarding the accuracy of generated information may pose risks to patients. The purpose of this study was to examine whether the information provided by LLMs regarding prostate Digital Poster 2817
lived experience, fostering confidence and trust. Preliminary insights from the GRACE project suggest that redesigned consent infrastructures could enhance autonomy, clarify expectations, and deepen reflection on decision-making in gynaecological radiotherapy. Conclusion: Radiotherapy practice benefits from integrating social science perspectives on infrastructure, emotion, relational labour, and consent, advancing a more human-centred and inclusive model of care. Together, these studies demonstrate how sociological approaches can complement technical innovation by strengthening communication, patient engagement, and system design. In line with the Lancet Oncology Commission’s call to re-centre the human dimensions of cancer care, this work offers practical directions for Innovating Radiation Oncology, Together. References: 1. Rodin G, et al. The human crisis in cancer: a Lancet Oncology Commission. The Lancet Oncology. 2025 [cited 2025 Nov 10]; Available from: https://www.thelancet.com/journals/lanonc/article/PII S1470-2045(25)00530-3/fulltext Keywords: human-centred care, service design, engagement Agreement between patient and physician- reported symptoms during radiotherapy for prostate cancer in the HYPO-RT-PC trial (ISRCTN45905321) Ulrika Rönningås 1,2 , Lars Beckman 3 , Anna-Karin Wennstig 2 , Per Fransson 1,3 1 Department of nursing, Umeå University, Umeå, Sweden. 2 Oncology department, Sundsvall Hospital, Sundsvall, Sweden. 3 Cancercentrum, Norrlands University Hospital, Umeå, Sweden Proffered Paper 2773
Purpose/Objective: Patients with prostate cancer treated with
radiotherapy may have many symptoms which may persist long after treatment. Physician-reported symptom assessments often do not agree with patient-reported assessments. Physicians tend to underrate symptoms rather than overrate them. Although previous studies have explored the agreement between patient- and physician-reported symptoms, there is a lack of studies using a prostate cancer-specific instrument developed explicitly for radiotherapy on a large sample size over a prolonged period. This study aimed to report and compare patient- and physician-reported symptoms before and after radiotherapy for prostate cancer over four years. Material/Methods:
Made with FlippingBook - Share PDF online