S2689
RTT - Patient experience and quality of life
ESTRO 2026
Results: In addition to the established relationship between head and neck cancer and deprivation, clear deprivation gradients were observed for mORN incidence (Graphs 1 and 2). The most deprived deciles contributed disproportionately to mORN cases. Specifically, a higher percentage of confirmed mORN cases were found in the lowest three IMD deciles compared to those without (52.5% vs 49.7%). This effect was more pronounced in the FOM subgroup (59.6% vs 49.7%). Conversely, a lower percentage of FOM patients with confirmed mORN were in the least deprived IMD deciles (8–10) compared to non-ORN patients in the same deciles (9.6% vs 14.5%).
Conclusion: The high number of patients consenting and completing AIR-PANC demonstrates feasibility, supported by scan tolerance. Streamlining sequences for phase 2 is a priority, to improve patient experience. Future work will present image analysis. References: [1] Barnes, H., Alexander, S., Bower, L., Ehlers, J., Gani, C., Herbert, T., Lawes, R., Møller, P.K., Morgan, T., Nowee, M.E. and Smith, G., 2021. Development and results of a patient-reported treatment experience questionnaire on a 1.5 T MR-Linac. Clinical and Translational Radiation Oncology, 30, pp.31-37.[2] Scott, N., Fayers, P., Aaronson, N., Bottomley, A., de Graeff, A., Groenvold, M., Gundy, C., Koller, M., Petersen, M.A. and Sprangers, M.A.G., 2008. EORTC QLQ-C30. Reference values. Brussels: EORTC.[3]https://www.eortc.org/app/uploads/sites/2/2 018/08/Specimen-PAN26-English.pdf Keywords: Functional MRI, RTT research, Pancreatic cancer Poster Discussion 5114 Socio-economic inequality and mandibular osteoradionecrosis: a hidden toxicity gap in head and neck cancer care Zoe E Davidson, Josef Kovarik, Muhammad Shahid Iqbal, Charles Kelly, Malcolm Jackson, Nick S West Cancer and Haematology, Northern Centre for Cancer Care, Newcastle upon Tyne, United Kingdom Purpose/Objective: Mandibular osteoradionecrosis (mORN) represents a severe late toxicity affecting a substantial proportion of head and neck cancer patients following radiotherapy. While high mandibular radiation dose is a key contributor, multiple socio-economic factors such as smoking, alcohol consumption, nutritional status, oral health, and the extent of dental extractions also influence risk (1,2). This study aims to investigate disparities in mORN incidence in relation to socio- economic inequality within a cohort of patients treated with radiotherapy for head and neck cancer. Material/Methods: In this retrospective study of 2,184 patients treated with radical radiotherapy for head and neck cancer, IMD scores were obtained from the English Indices of Deprivation 2019 (3). IMD scores were analysed by decile and mORN status, with decile 1 representing the 10% most deprived areas and decile 10 the least deprived 10%. Within the full cohort, 177/2,184 (8.1%) had confirmed mORN. A floor-of-mouth (FOM) sub- cohort had the highest incidence of mORN at 22.3% and was analysed separately.
Conclusion: Socio-economic status appears to be an independent modifier of toxicity risk beyond dosimetric exposure, with higher prevalence of mORN in areas of greater deprivation. While dose–volume and dental factors remain central, deprivation likely amplifies risk through behavioural and health inequalities.These
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