S2744
RTT - Patient preparation, immobilisation, and verification protocols
ESTRO 2026
Léon Bérard, Lyon, France. 3 UMR INSERM 1052-CNRS 5286, Centre de recherche en cancérologie de Lyon, Lyon, France. 4 Physical activity team, Centre Léon Bérard, Lyon, France. 5 Direction of clinical research and innovation, Centre Léon Bérard, Lyon, France. 6 Radiation therapy department, Centre Eugène Marquis, Rennes, France. 7 Radiation therapy department, Daniel Hollard Institut, Grenoble, France. 8 Radiation therapy department, Centre hospitalier universitaire de Saint Etienne, Saint Etienne, France. 9 Radiation oncology department, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland. 10 Radiation therapy department, Centre Oscar Lambret, Lille, France. 11 Radiation oncology department, Curie Institut, Paris, France
mean comparison. Only rotational deviations were evaluated, as these more accurately represent the reproducibility of the mask setup across treatment fractions, whereas translational discrepancies can arise from patient positioning rather than mask fit. Results: The study results in Table 1 show the inter-fraction variations of the three rotational shifts: pitch, roll, and yaw, during intracranial radiotherapy. The mean, standard deviation (SD) and range were compared between the two moulding methods. The pitch shows a statistically significant difference in mean (p=0.005) and SD (p=0.002). The mean and SD of roll and yaw showed no significant differences. For roll, both parameters were comparable, whereas for yaw, the means were similar but the SD was notably larger (0.70 vs 0.43). In addition, for all rotational axes, masks moulded without a base showed larger ranges.
Purpose/Objective: Radiotherapy for prostate cancer requires
reproducible positioning of the prostate, meaning recommendations that the rectum be empty at each session to limit rectal filling variation1. However, conventional methods (laxatives, enemas, anti- flatulents) have not proven their effectiveness2. The ETADAPT study evaluated the impact of therapeutic patient education (TPE) combining adapted physical activity (APA) and dietary management (eating habits, hydration), known to prevent constipation and gas, on
patient repositioning. Material/Methods:
Conclusion: This study demonstrates that using a head support during DSPS mask moulding improves interfraction setup reproducibility in intracranial radiotherapy, most notably in pitch rotation, with a consistent trend toward reduced yaw variability. Roll reproducibility was comparable between both methods. These findings indicate that incorporating a head support enhances occipital mask fit and may contribute to improved overall reproducibility and treatment accuracy. Keywords: mask, moulding, reproducibility
Patients (age>18) with prostate adenocarcinoma referred for RT as first-line (minimum 20 sessions) or post-operative treatment could be included (NCT04832113). Patients allocated to control arm (C) received standard care including written information on dietary advice. In the experimental arm (E), patients also received an educational assessment (two dietary TPE and one APA TPE workshops) before radiotherapy and a monitoring of their physical activity and diet goals every two weeks. Primary endpoint was the repositioning rate during radiotherapy. The hypothesis tested was a 30% decrease in the repositioning rate (estimated averages of 9 vs. 6 sessions). 108 patients per group were required. The secondary endpoints included patients’ proportion never repositioned, gastrointestinal toxicity grade ≥ 2, need for initiation of medication for intestinal transit, QoL, and changes in diet, hydration and activity. Results: Between June 2021 and August 2024, 221 patients were randomized in 4 centers. The median age was 74 years (range 53-87). No significant differences were observed regarding diabetes, high blood pressure and chronic inflammatory diseases. More patients lived alone in E than in C (91% vs 79%). On average, patients received 29 radiotherapy sessions. More patients showed a high level of physical activity (IPAQ score) in
Mini-Oral 4025 ETADAPT: a randomised, multicentre, phase 3 trial
to assess the effectiveness of therapeutic education on reproducibility for prostate radiotherapy
Pascale Roux 1 , Sophie Boisbouvier 2,3 , Alix Goerens 1 , Rodolf Mongondry 4 , Yaelle Ouldbey 5 , Sylvie Chabaud 5 , Ivana Sondarjee 5 , Séverine Metzger 5 , Manon Baty 6 , Coralie Hulot 6 , Olivia Diaz 7 , Claudia Fabre 7 , Thomas Reynaud 8 , Christelle Bonnefoy 8 , Salvatore Cozzi 9 , Cécile Laude 10 , Pascal Pommier 11 1 Nutrition team, supportive care, Centre Léon Bérard, Lyon, France. 2 Radiation oncology department, Centre
Made with FlippingBook - Share PDF online