S2774
RTT - RTT contouring, target definition, and treatment planning
ESTRO 2026
Conclusion: Evolution and Monaco demonstrated comparable geometric accuracy, which may partly have been influenced by the clinical GTV having originated from the Monaco-based GTV. Nevertheless, radiation oncologists consistently favored Evolution for its smoother contours. Evolution is feasible for abdominal MR-guided adaptive radiotherapy (MRgRT) and may streamline the daily workflow. References: 1. Bosma LS, Ries M, Denis de Senneville B, Raaymakers BW, Zachiu C. Integration of operator- validated contours in deformable image registration for dose accumulation in radiotherapy. Physics and Imaging in Radiation Oncology. 2023; 27:100483.2. van den Berg I, Savenije MHF, Teunissen FR, van de Pol SMG, Rasing MJA, van Melick HHE, Brink WM, de Boer JCJ, van den Berg CAT, van der Voort van Zyp JRN, Deep learning for automated contouring of neurovascular structures on magnetic resonance imaging for prostate cancer patients, Physics and Imaging in Radiation Oncology. 2023; 26:100453. Keywords: Contouring, MR-Linac, Abdominal MRgRT Mini-Oral 1643 The Results of Radiation Therapy (RT) Quality Assurance (QA) in the AGITG MASTERPLAN Phase II Clinical Trial Andrew J Oar 1 , Mark Lee 2 , Hien Le 3,4 , Dominique Lee 5,6 , David Pryor 5 , Julie Chu 7,8 , Anna Nicholson 9 , Dinesh Vignarajah 10,11 , Yuvnik Trada 12,13 , Iain Ward 14,15 , Leily Gholamrezaei 16 , Susan Brooks 17 , Tim Wang 18,13 , Adam Briggs 19 , John Shakeshaft 1 , Jaswinder Samra 20 , Alisha Moore 21 , Olivia Cook 21 , Rachael Dykyj 21 , Angela Whitehead 21 , Tamara Barry 5 , Aimee Devlin 5 , Katrin M Sjoquist 22,23 , David Goldstein 24,25 , Andrew Kneebone 26,27 1 Icon Cancer Centre, Gold Coast University Hospital, Southport, Australia. 2 Cancer Services, Liverpool Hospital, Liverpool, Australia. 3 Central Adelaide Local Health Network, SA Health, Adelaide, Australia. 4 School of Medicine, Adelaide University, Adelaide, Australia.
Results: Median DSC was 0.85 for Evolution (IQR 0.11, range 0.31) and 0.87 for Monaco (IQR 0.09, range 0.35). Median absolute HD was 6.46 mm for Evolution (IQR 3.62, range 7.89) and 5.62 mm for Monaco (IQR 2.47, range 7.97), and median MDA was 1.02 mm for Evolution (IQR 0.46, range 2.51) and 0.87 mm for Monaco (IQR 0.40, range 2.60) (Figure 2). Although geometric metrics were comparable, three radiation oncologists consistently preferred Evolution contours, selecting them in 78.6% cases versus 16.7% for Monaco, with 4.7% showing no clear preference. Notably, in 64% of fractions, all observers unanimously favored Evolution, often commenting that these contours appeared smoother, whereas unanimous preference for Monaco was not observed.
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