S1712
Physics - Dose prediction/calculation, optimisation and applications for particle therapy planning
ESTRO 2026
research version of the treatment planning system (TPS) RayStation to generate treatment plans for phantoms and mice. Plan delivery accuracy was verified with PTW ICs, comparing measured and TPS- calculated doses. Uncertainties were estimated for both simulation and experimental results, considering measurement precision, magnetic-field and material modelling accuracy in simulation, and data analysis methodology. Results: The MM and Giraffe detectors were demonstrated viable for SIRMIO beam characterization. Measured and simulated 80% dose fall-off positions agreed within 0.1 mm (Figure 1), beam FWHM sizes agreed within 0.2 mm at isocenter (Figure 2), and transmission efficiencies agreed within 4%. The MC model accurately predicted the position and shape of the scanned beam in IMPT delivery. TPS-calculated doses were consistent with PTW IC measurements. Consistent outcomes across 3 research campaigns spanning 3 years confirmed the reproducibility and robustness of the SIRMIO beamline.
Conclusion: The simulation model and beamline system were successfully commissioned and validated through extensive measurements demonstrating reliable and reproducible performance for in-vivo application in preclinical proton therapy research. References: This work was supported by ERC grant 725539 (SIRMIO). Beamtimes were provided within INSPIRE TNA (EU grant 730983) and HITRIplus (EU grant 101008548). The authors appreciate and gratefully acknowledge the support of the entire SIRMIO team and collaborators, in particular the DCPT, HIT and PSI teams and RaySearch Laboratories AB.[1] Kurichiyanil et al, 2025 Phys. Med. Biol.70 145007[2] Roberts and Kaplan, 2007 IEEE PAC[3] Huang et al, 2024 AAPM Los Angeles, USA[4] Bortfeldt et al, 2021 Joint Conference of ÖGMP, DGMP and SGSMP, Vienna, Austria[5] Bortfeldt et al, 2022 MPGD Rohovot, Israel Keywords: preclinical research, proton beamline, QA
Made with FlippingBook - Share PDF online