S1745
Physics - Dose prediction/calculation, optimisation and applications for particle therapy planning
ESTRO 2026
32.9.Lundberg, Scott M., et al. Nature Machine Intelligence 2.1 (2020): 56-67. Keywords: Carbon ion radiotherapy (CIRT), RBE models, LETd
predictive model revealed that, MKM doses DmMKM99% < 57–60 Gy (RBE) and steep mMKM dose gradients (Gradient D95-99%) were associated with a higher probability of LR (Fig 2).
Proffered Paper 2905
Reassessment of inter-center variation in SPR and range prediction within the European Particle Therapy Network Julian Schwengfelder 1,2 , Benjamin Ackermann 3 , Juan Diego Azcona Armendáriz 4 , Patrícia Cambraia Lopes 5 , Christina Vallhagen Dahlgren 6 , Ludovic de Marzi 7 , Gabriela Folty ń ska 8 , Francesco Fracchiolla 9 , Jeffrey Free 10 , Joanna Gora 11 , Andrew Gosling 12 , Matthew Lowe 13 , Ola Norrlid 14 , Jaime Martí 15 , Erik Pettersson 16,17 , Sima Qamhiyeh 18,19 , Ilaria Rinaldi 20 , Dorota Siewert 21 , Vicki Trier Taasti 22 , Alessandro Vai 23 , Vladimír Vondrá č ek 24 , Jörg Wulff 25 , Jens Zimmerman 26 , Nils Peters 27 , Christian Richter 1,2 1 OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany. 2 Helmholtz-Zentrum Dresden- Rossendorf, Institute of Radiooncology – OncoRay, Dresden, Germany. 3 Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany. 4 Service of Radiation Physics and Radiation Protection, Clínica Universidad de Navarra, Madrid, Spain. 5 HollandPTC, Protonen Therapie Centrum, Delft, Netherlands. 6 The Skandion Clinic, 6 The Skandion Clinic, Uppsala, Sweden. 7 Institut Curie, PSL Research University, Radiation Oncology Department, Proton Therapy Centre, Centre Universitaire, Orsay, France. 8 Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland. 9 UO Fisica Sanitaria, APSS, Trento, Italy. 10 University of Groningen, University Medical Center Groningen, Department of Radiation Oncology, Groningen, Netherlands. 11 MedAustron, Ion Therapy Center, Wiener Neustadt, Austria. 12 University College, London Hospitals, London, United Kingdom. 13 Christie Medical Physics & Engineering, The Christie NHS Foundation Trust, Manchester, United Kingdom. 14 Uppsala University Hospital, Dep. of Biomedical Engineering- Medical Physics and IT- Sec. for Medical Radiation Physics, Uppsala, Sweden. 15 Centro de Protonterapia, Quirónsalud, Madrid, Spain. 16 Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 17 Therapeutic Radiation Physics, Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden. 18 University Hospital of Leuven, Department of Oncology, Leuven, Belgium.
Conclusion: The DmMKM99% <57–60 Gy (RBE) and steep mMKM dose gradients were associated with a higher probability of LR, highlighting need to ensure adequate mMKM DRBE coverage to minimize the risk of local relapse especially when LEM-I model is used for primary optimization. References: 1.Fossati P, et. al. Physics in Medicine & Biology. 2012 Oct 26;57(22):7543.2.Molinelli S, et. al. Radiotherapy and Oncology. 2021 Oct 1;163:209-14.3.Molinelli S, et. al. Radiotherapy and Oncology. 2016 Aug 1;120(2):307- 12.4.Steinsträter, O., et. al. IJROBP, 84(3), pp.854- 860.5.Magro G, et. al. Physics in Medicine & Biology. 2017 Apr 11;62(9):3814.6.Joost JM Van Griethuysen, et. al. Cancer research 77.21 (2017), e104–e107.7.Leo Breiman. “Bagging predictors”. In: Machine learning 24.2 (1996), pp. 123–140.8.Leo Breiman. “Random forests”. In: Machine learning 45.1 (2001), pp. 5–
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