S1776
Physics - Dose prediction/calculation, optimisation and applications for particle therapy planning
ESTRO 2026
optimization of field geometry for total marrow irradiation delivered with volumetric modulated arc therapy. Med Phys. 2024; 51: 4402–4412. https://doi.org/10.1002/mp.17089[3] Yang Li and Tatsuya Harada. 2022. Non-rigid point cloud registration with neural deformation pyramid. In Proceedings of the 36th International Conference on Neural Information Processing Systems (NIPS '22). Curran Associates Inc., Red Hook, NY, USA, Article 2013, 27757–27768 Keywords: Non-Rigid Deformation, Autoplanning, TMI/TMLI Estimating impact on clinical proton range based on stopping power predictions from single- and dual-energy CT Erik Pettersson 1,2 , Anne Thilander Klang 1,3 , Callum Gillies 4 , Anna Bäck 1,2 1 Medical Radiation Sciences, Istitute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden. 2 Therapeutic Radiation Physics, Biomedical Engineering and Medical Physics, Sahlgrenska University Hospital, Gothenburg, Sweden. 3 Diagnostic Radiation Physics, Biomedical Engineering and Medical Physics, Sahlgrenska University Hospital, Gothenburg, Sweden. 4 Proton Therapy Physics, University College London Hospitals NHS Foundation Trust, London, United Kingdom Digital Poster 4323
could provide a standardised and quantifiable method for reducing inter-planner variability.
Purpose/Objective: To evaluate the impact on the clinical range
of a proton beam in patient tissues usingfour stopping power ratio (SPR) prediction methods based on single- and dual-energy CT (SECT and DECT).The evaluation was performed using two common sets of tissue surrogates. Material/Methods: Three soft tissue and four bone surrogate inserts (5 cm long, 3 cm diameter) from CIRSelectron density phantom (062A, CIRS Inc.) and five soft tissue and four bone surrogate inserts (5 cm long, 2.85 cm diameter)from Gammex AED phantom (Model 1467, Sun Nuclear) were used.Each insertwas placed one-by- one in a cylindrical (diameter 20 cm) polyethylene phantomin an excentric (offset 7.5 cm) insert position.The phantom was scanned with three different scanners, SOMATOM go.Open Pro (Siemens Healthineers), Spectral CT 7500 RT (Philips Healthcare) and Revolution Apex (GE Healthcare). SPR images were created with a clinical Hounsfield look-up table (HLUT) (SECT- images, SOMATOM go.Open Pro), DirectSPR (DECT- images, SOMATOM go.Open Pro), MMSim (DECT- images, Spectral CT 7500 RT) and MD-SPR (DECT-
Conclusion: We developed a deformation-based method to optimize isocenter positions and jaw apertures for TMI/TMLI. The generated geometries were clinically acceptable and matched expert quality. The method is dataset-independent, achieves results comparable to [2], and reduces manual effort while improving efficiency, making it suitable even for smaller centers. References: [1] Wong JYC, Filippi AR, Scorsetti M, Hui S, Muren LP, Mancosu P. Total marrow and total lymphoid irradiation in bone marrow transplantation for acute leukaemia. Lancet Oncol. 2020;21(10):e477-e487. doi:10.1016/S1470-2045(20)30342-9[2] Lambri N, Longari G, Loiacono D, et al. Deep learning-based
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