S2448
Physics - Radiomics, functional and biological imaging, and outcome prediction
ESTRO 2026
quality metric for arterial input functions, AIFitness7, and only the top 50 curves are kept (if fewer than 50 were found, all curves are kept). The VIF is created using each curve from the largest remaining cluster as follows:Linearly interpolate seven points between pairs of samples.Temporally align the curves to a template2 by cross correlation.Average the curves and downsample to the original temporal resolution, yielding the VIF. Results: The method was applied to three datasets: Head-and- neck8, brain9, and prostate10, showing plausible VIF- detections for every tested site, generally locating clusters inside major blood vessels in a few seconds.The method works across patients and anatomical sites, yielding similar VIFs for all patients for any given site (Figure 1).
Figure 2 illustrates differences in Ktrans-values computed using the extended Tofts model1 with a population-based VIF vs. an automatic patient-specific VIF. Conclusion: The proposed algorithm applies to several anatomical sites, creating reproducible results in seconds by finding clusters inside suitable blood vessels, from which a VIF is calculated. Choosing a population-based over a patient-specific VIF affects results and can have adverse effects on quantification3. References: 1Tofts P.S. JMRI, 1997.2Parker G.J.M., et al. Magn. Reson. Med., 2006.3Port R.E., Knopp M.V., Brix G. Magn. Reson. Med., 2001.4Stanisz G.J., et al. Magn. Reson. Med., 2005.5Billett H.H. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd ed. Ch. 151, 1990.6Ester M., et al. Proc. Conf. on KDD'96, 1996.7Saca L., et al. Magn. Reson. Med., 2025.8Ger R., et al. Figshare. doi.org/10.6084/m9.figshare.c.3901198.v1, 2017.9Fathi Kazerooni A., et al. OSIPI DCE Challenge. doi.org/10.17605/OSF.IO/U7A6F, 2023.10Fedorov A., et al. Data From QIN-PROSTATE-Repeatability. TCIA. doi.org/10.7937/K9/TCIA.2018.MR1CKGND, 2018. Keywords: DCE-MRI, vascular input function, perfusion
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