S2501
Physics - Radiomics, functional and biological imaging, and outcome prediction
ESTRO 2026
its applicability to RT toxicity analysis. Dose–response analysis highlighted the tubarial glands as highly dose- sensitive and more predictive of xerostomia than the parotid glands. These findings support their functional relevance and suggest that voxel-based analyses targeting symptom-related subregions within the tubarial glands may further improve xerostomia prediction and treatment planning. References: [1] Castelli J, Thariat J, Benezery K, et al. Weekly Adaptive Radiotherapy vs Standard Intensity- Modulated Radiotherapy for Improving Salivary Function in Patients With Head and Neck Cancer. A Phase 3 Randomized Clinical Trial. JAMA Oncol. 2023;9:1056–1064.[2] Valstar MH, de Bakker BS, Steenbakkers RJHM, et al. The tubarial salivary glands: A potential new organ at risk for radiotherapy. Radiother. Oncol. 2021;154:292–298. Keywords: xerostomia, tubarial glands, PSMA
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