Kolling Institute Special Research Feature

Fostering tomorrow’s research leaders

Pursuing research on type 1 diabetes

One of our emerging leaders in the cardiovascular and renal priority research area in 2023 was PhD student Amanda Purcell. Amanda is part of the Kolling Institute’s Renal Research Laboratory, working to improve treatment for those with diabetes and kidney disease.

Amanda Purcell

“Semaglutide is widely used in type 2 diabetes for weight loss and to improve how cells respond to insulin. “It is also used to delay progression of diabetic kidney disease in those with type 2 diabetes, but it is not known whether it would have these same benefits in those with type 1 diabetes. “Using a pre-clinical model, my project aims to determine if using semaglutide for those with type 1 diabetes and obesity can improve kidney health. “We hope the findings from this work will influence preventative care for diabetic kidney disease in people with type 1 diabetes and obesity.” JDRF Australia said it was passionate about not only supporting well established scientists who are leading the field, but also the best early-career researchers, to foster the pipeline and ensure breakthroughs continue to happen. The scholarships allow PhD scholars to attend scientific conferences, present their findings and establish critical networks with both national and international researchers.

She was one of only two researchers Australia-wide awarded a Juvenile Diabetes Research Foundation PhD Top-Up scholarship, aimed at supporting PhD students to pursue research on type 1 diabetes. The competitive scholarship selects the best and brightest scientists in the field to ensure the next generation of researchers can carry out their ground-breaking work. Amanda welcomed the support, which she said would help her develop new connections and share her findings. “The Juvenile Diabetes Research Foundation PhD scholarship represents an opportunity to create meaningful change and gives me the privilege to be part of a community dedicated to making a difference in the lives of people with type 1 diabetes,” she said. “This support will give me the chance to attend conferences and workshops, helping me connect with experts in the field and share my research findings.” Amanda is investigating a drug called semaglutide (a GLP-1 receptor agonist) to see if it can be used to treat diabetic kidney disease in those with type 1 diabetes and obesity. Type 1 diabetes often leads to complications including diabetic kidney disease, which can be life-threatening.

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