S1090
Clinical – Upper GI
ESTRO 2026
62.7% and 33.6%, respectively. Kaplan–Meier curves for OS, LC, and PFS are presented in Figure 1.
Conclusion: SBRT is a well-tolerated and effective option for elderly PC patients. When combined with chemotherapy, it may represent a valid non-surgical strategy or facilitate surgery in selected cases. Our results suggest that outcomes in elderly patients are not inferior to those observed in younger populations. Overall, SBRT appears to be a feasible and safe treatment alternative, offering encouraging local control and survival results with acceptable toxicity in a fragile patient group. Keywords: pancreatic cancer, SBRT, erderly patients Long-term outcomes of carbon-ion radiotherapy for hepatocellular carcinoma: A single-institutional retrospective analysis Shingo Toyama, Hiroaki Suefuji, Akira Matsunobu, Kotaro Terashima, Kaori Fukunishi, Wakana Ota, Yoshiyuki Shioyama Ion Beam Therapy Center, SAGA HIMAT Foundation, Tosu, Japan Purpose/Objective: To evaluate the efficacy and safety of carbon-ion radiotherapy (CIRT) for hepatocellular carcinoma (HCC). Material/Methods: A total of 227 patients with HCC who received CIRT between April 2014 and March 2019 were retrospectively analysed. Patient characteristics are summarised in the table. Poster Discussion 2988
As a general treatment policy, a dose of 48 Gy (RBE) in two fractions was prescribed for tumours ≤ 3 cm in diameter, and 60 Gy (RBE) in four fractions for tumours >3 cm. For lesions located close to organs of interest, alternative schedules, including 60 Gy (RBE) in 12 fractions, were employed. CIRT was delivered using a respiratory-gated passive scattering technique. The gross tumour volume (GTV) was delineated on the planning computed tomography (CT) by image fusion with contrast-enhanced magnetic resonance imaging. The clinical target volume was defined as the GTV plus a 4-mm margin, and the planning target volume included additional margins to account for set-up variations and respiratory motion, as assessed using four-dimensional CT. Among the patients treated in the initial period, 13 underwent placement of fiducial markers. Overall survival (OS), local control (LC), and progression-free survival (PFS) from the initiation of CIRT were estimated using the Kaplan–Meier method. A Cox proportional hazards model was used for multivariate analysis. Adverse events (AEs) were graded according to the Common Terminology Criteria for Adverse Events version 5.0. Liver function was further evaluated based on the occurrence of radiation-induced liver disease (RILD) and a ≥ 2-point increase in the Child–Pugh score. Results: The median follow-up duration was 44.6 months (range, 1.1–134.4) for the entire cohort and 68.1 months (range, 1.2–134.4) for the survivors. The 3-year and 5-year OS, LC, and PFS rates were 70.0% (95%
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