S1221
Clinical - Urology
ESTRO 2026
D).
Conclusion: Real-world evidence demonstrates that prostate cancer VMAT with peri-rectal spacer leads to significant rectal sparing, reduced incidence of early GI toxicity and improvement in bowel HRQOL. References: 1. Kishan AU, Sun Y, Tree AC, et al. Hypofractionated radiotherapy for prostate cancer (HYDRA): an individual patient data meta-analysis of randomised trials in the MARCAP consortium. Lancet Oncol. 2025 Apr;26(4):459-469. 2. Hamstra DA, Mariados N, Sylvester J, et al. Continued Benefit to Rectal Separation for Prostate Radiation Therapy: Final Results of a Phase III Trial. Int J Radiat Oncol Biol Phys. 2017 Apr 1;97(5):976-985. 3. Mariados NF, Orio PF 3rd, Schiffman Z, et al. Hyaluronic Acid Spacer for Hypofractionated Prostate Radiation Therapy: A Randomized Clinical Trial. JAMA Oncol. 2023 Apr 1;9(4):511-518. Keywords: Prostate cancer, peri-rectal spacer
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