S1236
Clinical - Urology
ESTRO 2026
The majority of patients were in a relationship (84%), with 77% being married. Prior to their cancer diagnosis, 39% were employed full-time, 5% part-time, 52 % retired and the remainder in other categories. At the time of completing the questionnaire, 6% were on sick leave, while 94% were either still working or retired. Patients rated the avoidance of genitourinary and gastrointestinal side effects as ‘important’ to ‘very important’. Clear information on potential toxicities and accessible clinical support were also highly valued. An efficient treatment, including a rapid start and a preference for shorter regimens, was strongly emphasized. Detailed results for the answers to the priorities are shown in figure 1.
stereotactic body radiotherapy to the prostate bed. Conclusion: Ultrahypofractionated postoperative salvage SBRT to the prostate bed is associated with high long-term local control rates and a favorable safety profile, supporting its use as an effective treatment option for patients with biochemical or clinical recurrences of
prostate cancer after radical prostatectomy. Keywords: salvage radiotherapy, prostate, hypofractionation
Digital Poster 2651
What matters most: Patient-reported preferences in prostate cancer radiotherapy - Results from the PersoRad project Sophia L. Bürkle 1,2 , Jürgen M. Giesler 3 , Paolina Toncheva 1,2 , Philipp M. A. Waibel 1,2 , Erik Farin- Glattacker 3 , Constantinos Zamboglou 4,1 , Anca-L. Grosu 1,2 , Simon K. B. Spohn 1,2 1 Department of Radiation Oncology, University Medical Center Freiburg, Freiburg, Germany. 2 Partner Site Freiburg, German Cancer Consortium (DKTK), Freiburg, Germany. 3 Section of Health Care Research and Rehabilitation Research, Institute of Medical Biometry and Statistics, Faculty of Medicine, University Medical Center Freiburg, Albert Ludwig University of Freiburg, Freiburg, Germany. 4 German Oncology Center, European University Cyprus, Limassol, Cyprus Purpose/Objective: Personalized radiotherapy (RT) for localized, intermediate- to high-risk prostate cancer (PCa) must integrate standard treatments and patient preferences. The PersoRad project evaluated the acceptance of digital questionnaires and explored individual RT preferences before treatment start. Material/Methods: Since 09/2022, a digital 6-point Likert questionnaire was accessed via QR Code or on-site tablets and
Significant differences between age groups (divided by median) were found for urinary toxicity (p=0.008), urethral complaints (p=0.032), preservation of erection (p<0.001), medical support (p=0.042) and increased life expectancy (p=0.002), with these factors being prioritized by the younger cohort. Conclusion: Differences in patient preferences and risk tolerance regarding potential side effects could be observed, with notable age-dependent variations particularly concerning erectile function, urinary symptoms and life expentancy. Digital data collection proved feasible in an older patient cohort and offers potential for routine digital questionnaire integration. Understanding individual priorities helps distinguish patients favoring safety from those prioritizing oncologic outcomes. Shared decision-making and patient-centered communication remain essential to optimize personalized radiotherapy in prostate cancer. Keywords: prostate cancer, therapy preferences Digital Poster 2669 Predictive value of PSA bounce after 1.5T MR- guided adaptive SBRT in a large cohort of prostate cancer patients. Andrea Romei 1 , Carolina Orsatti 2 , Andrea Gaetano Allegra 1 , Luca Nicosia 1 , Edoardo Pastorello 1 , Francesco Ricchetti 1 , Niccolò Giaj-Levra 1 , Chiara De-Colle 1 , Michele Rigo 1 , Ruggero Ruggieri 3 , Filippo Alongi 1,4 1 Department of Advanced Radiation Oncology, IRCCS Sacro Cuore Don Calabria Hospital, Cancer Care Center, Negrar di Valpolicella, Italy. 2 Department,
evaluated patient priorities on side effects (genitourinary and urethral symptoms;
gastrointestinal symptoms, diarrhea, constipation, rectal bleeding; sexual dysfunction) and treatment aspects (rapid start, medical support, short treatment duration) before treatment start. Additionally, sociodemographic data were collected. The project was completed with 110 patients recruited, including 8 dropouts. A total of 102 fully completed questionnaires were available for the final analysis. For further evaluation, the cohort was divided into two groups based on the median age, and differences between groups were assessed using two-tailed independent t-tests. Results: The cohort had a median age of 72 years (IQR 60-78).
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