S1294
Clinical - Urology
ESTRO 2026
April 2025. Data collected included sociodemographic and anthropometric variables (age, BMI), functional (G8 geriatric screening), and lifestyle assessment (physical activity using IPAQ and adherence to the Mediterranean diet using the MEDAS scale). The data collection form was administered to an initial cohort of 10 patients after informed consent. For the rest, the survey was self-administered after leaving the radiation oncology clinic. Clinical data were obtained from medical records. Results: The cohort of 94 patients had a median age of 74 years (range 57-86) and median BMI of 26 (range 20- 40). Most (69, 64.8%) had a G8 score ≥ 14.Regarding lifestyle, 40.7% (n=37) reported high physical activity, while 29.7% reported moderate 29.7%(n=27) and 29.7% (n=27) low activity. Moderate adherence to the Mediterranean diet was predominant with 68 patients (73.1%), followed by high adherence in 18 (19.4%) and low adherence in 7 (7.5%). 64.9% (n=61) who received ADT. Significant differences were detected in the time spent on moderate physical activity (p= 0.022), higher in participants with medium and high adherence to the Mediterranean diet compared to those with low adherence (M= 37.50± 22.75 minutes/day). Significant decreases in hemoglobin and leukocytes were observed after radiotherapy (p<0.001) and an increase in cholesterol treatment (p<0.028) accompanied by a non-significant trend towards an increase in triacylglycerols (p=0.067). Furthermore, throughout the study period (averaging pre and post RT), patients receiving ADT showed globally lower hemoglobin levels than those who did not receive it (p=0.007). A non-significant trend was observed towards greater practice of high and moderate physical activity in patients without actinic proctitis. High physical activity (days/week) was 4.71± 2.75 versus 2.47± 2.55 (p=0.076), and moderate activity showed higher values in days and duration (minutes) in the group without proctitis (4.08± 2.63 vs 5.57± 1.81) and 66.96 ± 75.44 vs 117.14 ± 61.30 respectively (p=0.078 in both cases). Conclusion: These results suggest a positive association between Mediterranean diet adherence and a more active lifestyle. Our patients exhibited high/moderate physical activity rates. Hemoglobin and leukocyte levels decreased after radiotherapy. ADT patients lost more hemoglobin than non-ADT patients. Patients with higher physical activity had lower incidence of actinic proctitis. References: Kerr J, Anderson C, Lippman SM. Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence. Lancet Oncol. 2017;18(8):e457-e471. doi:10.1016/S1470- 2045(17)30411-4Shephard RJ. Physical Activity and Prostate Cancer: An Updated Review. Sports Med.
patients were treated to one dose level and 152 to two dose levels. Mean CTV40Gy was 38.65 (33.2-57.5)cm3 and mean bladder volume 38.65 (30-50)cm3. Bladder V30Gy was associated with urinary toxicity at 6 months (OR 0.0095, 95% CI 0.000150.45, p=0.022). GU CTCAE grade 2+ toxicity was 4.6% at 6 months. Presence of urinary symptoms and urinary flow interventions showed a trend towards higher risk but were not statistically significant. Bladder volume was not associated with higher risk of GU toxicity. Conclusion: This study shows that an empty bladder treatment protocol is not associated with increased GU toxicity in patients undergoing ultrahypofractionated radiotherapy to the prostate. The PACE-B study reported 12% GU CTCAE grade 2+ toxicity in 6 months (ref 2) and our results are comparable. Further multicentre analysis would allow comparison of contemporary cohorts treated with partially filled and empty bladder approaches. References: 1. van As N, Griffin C, Tree A, Patel J, Ostler P et al. Phase 3 trial of stereotactic body radiotherapy in localized prostate cancer. N Engl J Med. 2024; 391 (15): 1413-14152. Tree AC, Ostler P, van der Voet H, Chu W, Loblaw A, Ford D, et al. Intensity-modulated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): 2-year toxicity results from an open-label, randomised, phase 3, non-inferiority trial. Lancet Oncol. 2022 Oct 1;23(10):1308–20. Keywords: Prostate, ultrahypofractionation, toxicity Digital Poster 4266 The starting point beyond PSA: Characterization of physical activityand metabolic parameters in patients with prostate cancer. Priscila Bernard 1 , Marta Bonet 1 , David González 1 , Sebastiá Mas 2 , Pilar Perez 3 , Virginia García 1 , Sara Vázquez 1 , Jose Baquedano 1 , Elena García 1 , Manuela Bermudez 1 , Judith Arbós 2 , Pol Porta 2 , Esther Chiné 1 , Oriol Torne 1 , Moises Mira 1 1 Radiation Oncology, Hospital Arnau de Vilanova, Lleida, Spain. 2 INEFC, INEFC, Lleida, Spain. 3 Student, UdL, Lleida, Spain Purpose/Objective: To determine the baseline prevalence of physical activity levels and metabolic parameters in patients diagnosed with prostate cancer starting combined treatment with radiotherapy and androgen deprivation therapy (ADT). Material/Methods: A cross-sectional descriptive study was conducted, including 94 patients with prostate cancer treated with radiotherapy and ADT between December 2024 and
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