S1305
Clinical - Urology
ESTRO 2026
hemoglobin (p = 0.077). Those who danced exhibited lower glucose (99 ± 13 vs 110 ± 11 mg/dL; p = 0.050), greater walking frequency (p = 0.028), and higher mediterranean diet adherence (p = 0.021). Conclusion: OncoAthletes is a feasible and safe hybrid exercise prescription program for prostate cancer patients under ADT and radiotherapy, improving physical fitness and maintaining metabolic stability. Medium- term adherence remains a challenge. Although no statistical association was observed between music interest and baseline activity, music and movement may serve as innovative motivational strategies to enhance engagement and long-term adherence in future interventions. Keywords: Prostate cancer, Exercise, Motivation Digital Poster 4757 Three Rounds of Radiotherapy for Prostate Cancer: Assessing Feasibility and Outcomes of a Third Treatment for Prostate Cancer Local Recurrence Costantino Putzu 1 , Federico Mastroleo 1,2 , Dario Zerini 1 , Giovanni Carlo Mazzola 1 , Chiara Lorubbio 1 , Maria Giulia Vincini 1 , Federica Cattani 3 , Francesca Emiro 3 , Gennaro Musi 4 , Giuseppe Petralia 5 , Giulia Marvaso 1,2 , Barbara Alicja Jereczek-Fossa 1,2 1 Department of Radiotherapy, IEO, European Institute of Oncology, Milan, Italy. 2 Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy. 3 Unit of Medical Physics, IEO, European Institute of Oncology, Milan, Italy. 4 Department of Urology, IEO, European Institute of Oncology, Milan, Italy. 5 Department of Radiology, IEO, European Institute of Oncology, Milan, Italy Purpose/Objective: This retrospective, single-centre study represents an updated and expanded analysis of a previously published series of patients1 undergoing a third course of radiotherapy (RT) for locally recurrent prostate cancer (PCa). Building upon the original cohort, we now provide updated follow-up (FUP) data and also include additional patients treated with a third course of RT using proton therapy (PT). Material/Methods: Inclusion criteria were as follows: (1) histologically confirmed PCa initial diagnosis; (2) history of two prior courses of RT targeting the prostate gland or the prostate bed; (3) no evidence of greater than grade 2 CTCAE genitourinary (GU) or gastrointestinal (GI) late events from previous treatments; (4) diagnosis of a isolated single local recurrence at the restaging imaging after second RT biochemical recurrence. Primary endpoint was toxicity profile via incidence of CTCAE grade ≥ 3 genitourinary (GU) and
Digital Poster 4714 Feasibility and metabolic effects of a hybrid exercise prescription program in prostate cancer patients under ADT and radiotherapy Marta Bonet 1,2 , David González 1 , José-Enrique Baquedano 1 , Pilar Perez 2 , Priscila Bernard 1 , Elena García 1 , Judith Arbos 3 , Pol Porta 4 , Natalia Castel 4 , Jaume Peñarroja 4 , Enoa Fernandez 4 , Mari Soler 4 , Alvaro Serrano 4 , Esther Chine 1 , Oriol Torne 1 , Maria Cagigós 1 , Aline Magalhaes 5 , Melissa Mercadal 5 , Moises Mira 1 , Sebastia Mas-Alos 4 1 Radiation Oncology Department, Arnau de Vilanova University Hospital, Lleida, Spain. 2 Facultat de Medicina, Universitat de Lleida, Lleida, Spain. 3 National Institute of Physical Education of Catalonia, Pirineus campus, University of Lleida, La Seu d'Urgell, Spain. 4 National Institute of Physical Education of Catalonia, Lleida Campus, University of Lleida, Lleida, Spain. 5 Education and Art Mediation, Escola Superior de Música de Cataluña, Barcelona, Spain Purpose/Objective: To assess the feasibility and metabolic outcomes of the OncoAthletes hybrid exercise prescription training program in prostate cancer patients under androgen deprivation therapy (ADT) and radiotherapy, and to investigate whether musical engagement (singing, dancing) could serve as a motivational factor for long- term adherence to exercise. Material/Methods: Pre-experimental single-group study including 24 men (mean age 73 ± 5.9 years; BMI 28.1 ± 3.7) receiving ADT and radiotherapy at the University Hospital Arnau de Vilanova (Lleida, Spain). The intervention was a 4- week supervised strengthening exercise followed by 12 weeks of online supervision. Senior Fitness Test, EQ-5D-5L, and ClassAF were assessed pre/post. Blood parameters (lipids, glucose, hemoglobin, leukocytes) were analyzed before and after treatment. A complementary questionnaire explored music-related habits (singing, dancing). Results: Of 24 participants, 23 completed the program; 77 % improved physical fitness and 75 % increased activity level.Adherence during the hybrid phase was high but dropped after supervision ceased; at 3 months, 22 % continued exercising regularly, 28 % abandoned, 11 % exercised irregularly, and 39 % did not respond.Leukocytes decreased from 6.4 ± 2.4 × 10 ⁹ /L to 4.3 ± 2.4 × 10 ⁹ /L (F = 10.3; p = 0.004). LDL-cholesterol decreased from 103.4 ± 62.2 mg/dL to 89.4 ± 67.3 mg/dL (F = 5.23; p = 0.037), while other lipids and glucose remained stable.Participants who enjoyed singing showed lower baseline glucose (110 ± 10 vs 96 ± 12 mg/dL; p = 0.014) and triglycerides (158 ± 80 vs 92 ± 52 mg/dL; p = 0.025), with a trend toward higher
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