S1397
Interdisciplinary - Health economics & health services research
ESTRO 2026
was used as primary (n=217, 70%), adjuvant (n=92, 30%) or neoadjuvant treatment (n=16, 5%), and techniques evaluated included external beam (n=213, 69%), stereotactic (n=70, 23%), brachytherapy (n=45, 15%), and protons (n=37, 12%). A decision analytic model was the most common method for economic evaluation (n=221, 72%). Most studies reported sensitivity analyses (n=273, 88%), with an increase in multivariable (n=183, p < 0.001) and probabilistic sensitivity analyses per time period (n=165, p < 0.001), peaking between 2011-2015, Figure 1. CEAs are increasingly reported as incremental cost- effectiveness ratios (ICER) (n=257, p=0.002), reaching their highest frequency between 2011-2015, and incremental cost utility ratio (ICUR) (n=245, p=0.001) have also become more commonly reported over time, Figure 2.
Digital Poster Highlight 1954 Health Economics Publications in Radiation Oncology: A Systematic Review Cecilia Tran 1 , Vivian S Tran 2 , Adam Mutsaers 2 , Andrew Warner 2 , Andrew Youssef 3 , Timothy K Nguyen 2 , Adesh Suchit 4 , Gabriel Boldt 5 , David A Palma 2 , Gregory Zaric 6 , X. Melody Qu 2 , Alexander V Louie 7 1 Faculty of Medicine, University of Ottawa, Ottawa, Canada. 2 Department of Radiation Oncology, London Regional Health Sciences, London, Canada. 3 Institute for Medical Sciences, University of Toronto, Toronto, Canada. 4 Schulich School of Medicine and Dentistry, Western University, London, Canada. 5 Clinical Research Library, London Regional Health Sciences, London, Canada. 6 Richard Ivey School of Business, Western University, London, Canada. 7 Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada Purpose/Objective: Technologic innovation and evolving utilization of radiotherapy (RT) in oncology calls for rigorous evaluation of cost-effective analyses (CEAs) to guide evidence-based health policy. The aim of this study was to evaluate the quality and trends in CEAs involving RT. Material/Methods: A systematic review of RT cost-effectiveness and cost- utility studies was conducted using PubMed and Embase from inception through December 31, 2024. Non-English publications, reviews, abstracts, and cost- only analyses were excluded. Two reviewers independently screened studies and extracted data on demographics, economic measures, and methodology, with discrepancies settled by a third. Studies were stratified into 4 time periods, descriptive statistics were reported, and the Cochran-Armitage trend test was used to identify temporal trends. Results: Of 3353 screened abstracts, 309 articles were included for full-text review. The 4 time periods were as follows: 53 articles in 1995-2010 (17.2%), 62 in 2011-2015 (20.1%), 104 in 2016-2020 (33.7%), and 90 in 2021-2025 (29.1%). Most publications originated from North America (n=158, 52%), Europe (n=67, 22%), and Asia (n=56, 18%), and the most common currencies reported were USD (n=193, 63%) followed by EUR (n=41, 13%). Reporting of conflict of interest (p < 0.001) and sponsorship (p=0.005) improved over time. Common disease sites included: genitourinary (n=49, 16%), breast (n=46, 15%), head-and-neck (n=43, 14%), gastrointestinal (n=38, 12%) and lung (n=35, 11%). Treatment intent was primarily curative (n=257, 83%), and less commonly palliative (n=49, 16%), in the context of early stage (n=122, 40%), locally advanced (n=153, 50%), and metastatic (n=32, 10%) disease. RT
Conclusion: CEAs are increasingly utilized to provide meaningful insight for how to effectively deploy radiotherapy (RT). Increased relative reporting of ICER, ICUR, the use of sensitivity analyses, and improved reporting of conflicts and funding suggest that the quality of CEAs may be improving over time. Keywords: cost-effectiveness, systematic review
Digital Poster 2112
The hidden burden of cancer care: A cross sectional study of financial toxicity among Tunisian patients undergoing radiotherapy Salma Ghorbel, Farah Ben Aissa, Mouna Ben Rejeb, Lilia Ghorbal, Awatef Hamdoun, Lotfi Kochbati
Made with FlippingBook - Share PDF online