S1400
Interdisciplinary - Health economics & health services research
ESTRO 2026
between 2020 and 2025. Proportions of patients with indications for radiotherapy were derived primarily from Australian population-based data. Guideline- recommended fractionation schedules were assigned to each indication. The optimal radiotherapy utilisation rate was determined by calculating the proportion of patients for whom radiotherapy is indicated. The overall optimal number of fractions was determined by weighting each fractionation schedule according to the frequency of specific clinical scenarios. Sensitivity analyses were performed to assess impact of uncertainties on model estimates. Results: The optimal radiotherapy utilisation in breast cancer was estimated to be 80.4% (range 78.5% - 82.1%) with an estimated optimal number of fractions per patient of 11.2 (range 8.6-20.5), based on the updated evidence-based guidelines (Figures 1 and 2). Radiotherapy is recommended in 63.8% of DCIS and 82.8% of invasive breast cancer patients, with estimated optimal number of fractions per patient of 9.4 and 11.5, respectively.
Conclusion: The estimated optimal radiotherapy utilisation rate and number of fractions per patient in breast cancer are lower compared to the previous modelling. This study provides updated benchmarks for the optimal use of radiotherapy in breast cancer to support efficient resource planning. The model can be adapted to different populations to evaluate access, efficiency, and cost-effectiveness, helping guide equitable and evidence-based radiation oncology care. References: 1. Barton MB, F.M., Olver I, Cox X, et al, A cancer services framework for Victoria and future directions for the Peter MacCallum Cancer Institute. A report from a consortium led by the Collaboration for Cancer Outcomes Research and Evaluation (CCORE).2. Scottish Executive Health Department and Radiotherapy, Activity Planning Group. Radiotherapy activity planning for Scotland 2001–2015.3. Bentzen, S.M., et al.,. Radiother Oncol, 2005. 75(3): p. 355-65.4. Wong, K., G.P. Delaney, and M.B. Barton. Radiother Oncol, 2015. 116(2): p. 174-8.5. Barton, M.B., et al. Radiother Oncol, 2014. 112(1): p. 140-4.6. Wong, K., G.P. Delaney, and M.B. Barton. Radiother Oncol, 2016. 119(1): p. 145-9.7. Delaney, G., et al. Cancer, 2005. 104(6): p. 1129-37. Keywords: Optimal, Radiotherapy, Breast cancer
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