S1409
Interdisciplinary - Health economics & health services research
ESTRO 2026
Western Sydney Local Health District, Sydney, Australia. 4 Westmead Clinical School, University of Sydney, Sydney, Australia Purpose/Objective: Previous modelling in 2012 identified that 77% of patients with lung cancer have evidence-based indications for radiotherapy1 and the estimated average fractions for the first course of radiotherapy was 12.12. Over the past decade, there have been substantial changes in lung cancer management, led by the increased uptake of advanced radiotherapy techniques, targeted therapies and immunotherapies, as well as the recognition of oligometastatic disease and oligoprogression in advanced disease. The epidemiology of lung cancer patients with indications for radiotherapy has also changed over time. The aim of this study was to update the estimate of the proportion of lung cancer patients who would be eligible for radiotherapy in Australia and the optimal number of fractions for the first course of radiotherapy. Material/Methods: The methodology was based on the Collaboration for Cancer Outcomes Research and Evaluation’s (CCORE’s) model for optimal radiotherapy utilisation, originally constructed in 20033 and updated in 20121. Indications for radiotherapy and recommended fractionations were extracted from national and international evidence-based guidelines on lung cancer treatment published from 2020-2025. Epidemiological data on the proportions of patients with each indication for radiotherapy were also extracted from the literature. Epidemiological data and indications were merged to create an optimal radiotherapy utilisation tree. An optimal radiotherapy fractionation tree was developed from the optimal radiotherapy utilisation tree. Univariate sensitivity analyses were performed to account for uncertainties on model estimates. Results: The updated estimation of all patients with lung cancer with an evidence-based indication for radiotherapy is 65% (range of 63-67%). 67% of patients with small cell lung cancer (SCLC) and 65% of those with non-small cell lung cancer (NSCLC) are estimated to be eligible for radiotherapy. The average fractionation for the first course of radiotherapy in all lung cancers is 6.0 fractions (range of 4.7-7.9).
Conclusion: The estimated optimal radiotherapy utilisation and the optimal number of fractions for radiotherapy in lung cancer is lower when compared to the previous model. This model can be adapted in the future to keep pace with developments in lung cancer control. References: 1. Barton MB., Jacob S., Shafiq J., Wong K., Thompson SR., Hanna T., Delaney GP. Estimating the demand for radiotherapy from the evidence: a review of changes from 2003 to 2012. Radiotherapy and Oncology 112(1):140-144, 2014 2. Wong K., Delaney GP., Barton, MB. Evidence-based optimal number of radiotherapy fractions for cancer: A useful tool to estimate radiotherapy demand. Radiotherapy and Oncology 119(1):145-149, 20163. Delaney G., Jacob S. Barton M., Jalaludin B. A model for decision-making for the use of radiotherapy in lung cancer. Lancet Oncology, 4(2): 120-128, 2003 Keywords: radiotherapy, utilisation, fractions Digital Poster 2949 A Virtual MR-linac Center: Equal Access, Shared Innovation and Expertise Laura A Rechner 1 , Mette Pøhl 2 , Susanne N Bekke 1 , Susan BN Biancardo 1 , Anne L Cappelen 2 , Sussi Christensen 2 , Katrin E Håkansson 2 , Ida A Jakobsen 2 , Tammie MS Jensen 2 , Henriette Lindberg 1 , Lene S Mouritsen 1 , Cecile Peucelle 2 , Gitte Persson 1 , Peter M Petersen 2 , Keerthana Ratnarajah 2 , Signe L Risumlund 2 , Betina Rotbøll 2 , Marianne F Rønjom 1 , Grichar V Santurio 1 , Filippa Sundbye 1 , Bob Smulders 2 , Rebecca J Tobin 2 , Isak Wahlstedt 2 , Kristian Boye 2 , Mette VO Felter 1 1 Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte Hospital, Herlev,
Made with FlippingBook - Share PDF online