S145
Brachytherapy - Physics
ESTRO 2026
complex needle geometries involving close spacing and crossovers. The algorithm demonstrated robustness to image variability and missing data, maintaining stable performance without manual correction. Full reconstruction of both pre and post- treatment CT volumes completed within approximately 30 seconds per patient, indicating potential for clinical integration. Conclusion: An automated method for needle trajectory reconstruction in HDR prostate brachytherapy has been developed and validated on 11 clinical datasets. The integration of Kalman filtering with Mahalanobis distance matching enables fast, accurate and reliable reconstruction of needle trajectories. This approach substantially reduces manual workload and provides a robust foundation for future automatic displacement quantification, supporting a more consistent and [1] Whitaker M et al. Prostate HDR brachytherapy catheter displacement between planning and treatment delivery. Radiother Oncol. Dec 2011[2] Moradi MM et al. Fully automatic reconstruction of prostate high-dose-rate brachytherapy interstitial needles using two-phase deep learning-based segmentation and object tracking algorithms. Clin Transl Radiat Oncol. Jan 2025[3] Wang F et al. Deep efficient clinical workflow. Keywords: HDR, prostate References: learning applications in automatic needle segmentation in ultrasound-guided prostate brachytherapy. Med Phys. Sep 2020[4] Weishaupt LL et al. Approaching automated applicator digitization from a new angle: Using sagittal images to improve deep learning accuracy and robustness in high-dose- rate prostate brachytherapy. Brachytherapy. Jul-Aug 2022 Exploring TCP and NTCP trade-offs in multi-criteria optimization for HDR gynecological brachytherapy Armance Volta 1,2 , Marie-Claude Lavallée 2 , William Foster 3,4 , Luc Beaulieu 1,2 1 Département de physique, de génie physique et d'optique, Université Laval, Québec, Canada. 2 Département de Radio-Oncologie et Centre de Recherche en Cancérologie de l'Université Laval, Centre hospitalier universitaire de Québec, Québec, Canada. 3 Service de Radio-oncologie, Département de médecine spécialisée, Faculté de Médecine, Université Laval, Québec, Canada. 4 Axe Oncologie, Centre de recherche, CHU de Québec-Université Laval, Québec, Canada Digital Poster Highlight 4511
Digital Poster 4516
Updated dosimetric comparison of HDR interventional radiotherapy (modern brachytherapy) with Cobalt-60 versus VMAT and electron beam therapy for NMSC Elisa Placidi 1 , Sidra Sajjad 2 , Muhammad Shahban 3 , Enrico Rosa 1,4 , Bruno Fionda 1 , Humera Mehmood 3 , M. Basim Kakakhel 2 , Maria Antonietta Gambacorta 1,5 , Luca Tagliaferri 1,5 , Marco De Spirito 1,6 1 Dipartimento di Diagnostica per Immagini e Radioterapia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. 2 Pakistan Institute of, Engineering and Applied Sciences (PIEAS), Islamabad, Pakistan. 3 Nuclear Medicine, Oncology and Radiotherapy Institute (NORI), Islamabad, Pakistan. 4 Department of Theoretical and Applied Sciences, eCampus University, Rome, Italy. 5 Dipartimento di Scienze Radiologiche, Università Cattolica del Sacro Cuore, Rome, Italy. 6 Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy Purpose/Objective: This study represents an update and external validation of our previously published work [1], which compared Iridium-192 (Ir-192) high-dose-rate interventional radiotherapy (HDR-IRT, modern brachytherapy) with Volumetric Modulated Arc Therapy (VMAT) and Electron Beam Therapy (EBT) for non-melanoma skin cancer (NMSC). In this validation, a second independent institution replanned the same 25 patient datasets using a Cobalt-60 (Co-60) source to assess the reproducibility of results across centers and A retrospective study of 25 patients previously treated with HDR-IRT using Ir-192 source was replanned with Co-60 HDR-IRT, VMAT, and EBT with three different prescription scenarios (Group A 54 Gy in 18 fractions, Group B 50 Gy in 20 fractions and Group C 40 Gy in 8 fractions). All plans were evaluated by keeping V95% constant to ensure radioactive sources. Material/Methods:
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