S183
Clinical - Biomarkers of clinical response
ESTRO 2026
between November 2014 and March 2025, were retrospectively analyzed. Baseline characteristics included age, performance status and HPV/p16 status. NLR and PLR before CRT and post-CRT were calculated. Cut-off points were defined by the median values. Survival outcomes were estimated by Kaplan– Meier analysis, with group comparisons using the log- rank test. Results: Fifty-four patients were included. Median age of 60 years (range 36–82) and good performance status (ECOG 0–1 in 92%). HPV/p16 positivity was observed in 80%. The mean NLR and PLR before CRT were 2.42 and 142.5, increasing to 6.50 and 361.3 post-CRT, respectively. Cut-off points were defined by the median values (NLRpre 2.15, NLRpost 4.47, PLRpre 123.7, PLRpost 258).After a median follow-up of 92 months, 85% of patients were alive and local and distant disease-free. Eight deaths (14.8%) occurred, seven related to the primary tumour. Colostomy was required in 7% of patients, and distant metastases developed in 11%. Median OS for the whole cohort was 119 months, with 3- and 5-year OS rates of approximately 93% and 85%, respectively. Colostomy- free survival (CFS) at 5 years was 90%, and local relapse-free survival (LRFS) 89%. When stratified by inflammatory indices, no statistically significant differences were observed in OS or LRFS for low vs. high groups: NLRpre (<2.15 vs >2.16): χ² =1.42, p=0.23; NLRpost (<4.47 vs >4.48): χ² =0.19, p=0.66; PLRpre (<123.7 vs >123.8): χ² =2.36, p=0.12; PLRpost (<258 vs >258.01): χ² =0.47, p=0.49. However, patients with higher NLR and PLR tended to have slightly shorter OS and more frequent treatment-related toxicity ( ≥ G3 in 32%). Conclusion: In this single-institution series, CRT achieved high rates of local control and colostomy-free survival with low treatment-related mortality. Although no significant correlation was found between NLR or PLR and survival outcomes, the post-treatment rise in both ratios may reflect systemic inflammatory response to CRT. Further evaluation in larger, multicentre cohorts and multivariate analyses is warranted to clarify the prognostic role of these indices. Keywords: anal-carcinoma, inflammatory-Biomarkers
Quality control using homolateral muscle measurements confirmed stable, literature-consistent values. Tumors exhibited low hypoxia (median pretreatment rOEF <22%), corroborated by multiplex immunofluorescence showing minimal CA9+ cell density. Post-nRT, significant increases in ADC (Apparent Diffusion Coefficient) and Dslow (reflecting reduced cellularity) and decreases in T2* and SvO2 (indicating reduced oxygenation) were observed. The percentage of viable cells in surgical specimens correlated with pretreatment R2’ (R=0.5, p=0.03) and strongly with rOEF and SvO2 (|R|=0.7, p<0.001), suggesting their predictive potential. Conclusion: This mpqMRI protocol for STS can be run in routine clinical exam, offering precise tumor characterization. Early results indicate that quantitative parameters like rOEF and SvO2 may predict treatment response, supporting future trials for personalized therapy and imaging biomarker development. Keywords: quantitative MRI, sarcomas, hypoxia Clinical outcomes and prognostic value of inflammatory Biomarkers (NLR and PLR) in patients with anal canal carcinoma treated with chemoradiotherapy Barbara G Salas- Salas 1 , Nereida Rodríguez-González 1 , Laura Ferrera-Alayon 1 , Antonio Alayón Afonso 1 , Alexandra Hre š ková 1 , Alba López-Carmona 1 , Gemma Calvet-Molinas 2 , Marta Lloret-Saez-Bravo 1 1 Department of Radiation Oncology, University Hospital Dr Negrín, Las Palmas de Gran Canaria, Spain. 2 Department of Radiation Oncology, University Hospital Santa Creu i Sant Pau, Barcelona, Spain Purpose/Objective: To evaluate the potential prognostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to- lymphocyte ratio (PLR) before and after chemoradiotherapy (CRT) in patients with anal-canal squamous cell carcinoma, and outcomes treatment overall survival (OS), colostomy-free survival (CFS), and local control. Material/Methods: Patients with histologically confirmed anal canal carcinoma treated with definitive concurrent CRT Digital Poster 1681
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Sex-specific signals in abscopal responses with radiotherapy plus immune checkpoint inhibition: a multicentre real-world analysis Maike Trommer 1,2 , Alexander Rühle 3,4 , Felix Ehret 5,6 , Allison Lamrani 7 , Charlotte Frei 7,8 , Justus Kaufmann 9 , Matthias Mäurer 10,11 , Georg Wurschi 10,12 , Ping Jiang 13 ,
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